Mostrar el registro sencillo del ítem

AutorRaboni, Sonia M.
AutorBonfim, Carmem
AutorAlmeida, Bernardo M.
AutorZanluca, Camila
AutorKoishi, Andrea Cristine
AutorRodrigues, Paula R. V. P.
AutorKay, Claudia K.
AutorRibeiro, Lisandro L.
AutorScola, Rosana H.
AutorDuarte Dos Santos, Claudia N.
Fecha de acceso2017-03-29T19:41:05Z
Fecha de disponibilización2017-03-29T19:41:05Z
Fecha de publicación2017
ReferenciaRABONI, Sonia M. etal. Flavivirus cross-reactivity in serological tests and Guillain-Barré syndrome in a hematopoietic stem cell transplant patient: A case report. Transplant Infectious Disease, p. 1-14, Mar. 2017
URIhttps://www.arca.fiocruz.br/handle/icict/18202
Idiomaengen_US
EditorWiley
Derechos de autoropen access
Palabras clave en PortuguésVirus da Denguept_BR
Palabras clave en PortuguésZika Viruspt_BR
Palabras clave en PortuguésSíndrome de Guillain Barrept_BR
TítuloFlavivirus cross-reactivity in serological tests and Guillain-Barré syndrome in a hematopoietic stem cell transplant patient: a case reporten_US
Tipo del documentoPreprint
DOI10.1111/tid.12700
Resumen en InglésSerological diagnosis of flavivirus infection is a challenge, particularly in the context of a disease associated with immune response enhancement in a transplant patient, where aspects such as previous flavivirus infections may be involved with the outcome. We report a case of a pediatric patient who developed Guillain-Barré syndrome (GBS) after matched-unrelated hematopoietic stem cell transplantation (HSCT). The patient lives in a Brazilian region that is experiencing an epidemic of Zika virus (ZIKV) and dengue virus (DENV). Because an increasing number of cases of GBS, likely triggered by ZIKV infection, are being reported in Brazil, samples from the patient were tested for both ZIKV and DENV infection. Serological assays strongly suggested a recent ZIKV infection, although infection by DENV or co-infection with both viruses cannot be ruled out. The presence of anti-DENV immunoglobulin-G in donor serum led to the hypothesis that antibodies from the donor could have enhanced the severity of the ZIKV infection. This hypothesis is in agreement with the recent findings that DENV sero-cross-reactivity drives antibody-dependent enhancement of ZIKV infection. These findings highlight the need for discussion of the indication to perform previous flavivirus tests in HSCT donors, especially in areas where ZIKV and other flaviviruses co-circulate. This article is protected by copyright. All rights reserved.en_US
AfiliaciónUniversidade Federal do Paraná. Laboratório de Virologia. Paraná, PR, Brasil.
AfiliaciónUniversidade Federal do Paraná. Divisão de Transplantes. Paraná, PR, Brasil.
AfiliaciónUniversidade Federal do Paraná. Hospital de Epidemiologia. Paraná, PR, Brasil.
AfiliaciónFundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.
AfiliaciónFundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.
AfiliaciónUniversidade Federal do Paraná. Divisão de Neurologia. Serviço de Doença Neuromuscular. Paraná, PR, Brasil.
AfiliaciónUniversidade Federal do Paraná. Divisão de Neurologia. Serviço de Doença Neuromuscular. Paraná, PR, Brasil.
AfiliaciónUniversidade Federal do Paraná. Divisão de Transplantes. Paraná, PR, Brasil.
AfiliaciónUniversidade Federal do Paraná. Divisão de Neurologia. Serviço de Doença Neuromuscular. Paraná, PR, Brasil.
AfiliaciónFundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.
Palavras clave en InglêsGuillain-Barré Syndromeen_US
Palavras clave en InglêsDengue Virusen_US
Palavras clave en InglêsHematopoietic Stem Cell Transplantationen_US
Palavras clave en InglêsZika virusen_US
Documento revisadoNão
Estado de publicaciónNão Publicado


Ficheros en el ítem

application/pdf
Nombre:
ve_Sonia_M_Raboni_etal_2017.pdf
Tamaño:
242.1Kb
Formato:
application/
Ver/Abrir

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem