| Author | Marques, Letícia Helena dos Santos | |
| Author | Rocha, Iara Caixeta da | |
| Author | Reis, Ilka Afonso | |
| Author | Cunha, Gisele Macedo Rodrigues da | |
| Author | Oliveira, Edward Jose de | |
| Author | Pfeilsticker, Thais Ribeiro | |
| Author | Araújo, Valdelaine Etelvina Miranda de | |
| Author | Morais, Maria Helena Franco | |
| Author | Rabello, Ana Lucia Teles | |
| Author | Carneiro, Mariângela | |
| Access date | 2017-04-03T18:23:43Z | |
| Available date | 2017-04-03T18:23:43Z | |
| Document date | 2016 | |
| Citation | MARQUES, Letícia Helena dos Santos et al. Leishmania infantum: illness, transmission profile and risk factors for asymptomatic infection in an endemic metropolis in Brazil. Parasitology, v. 144, n. 4, p. 546-556, 2017 | pt_BR |
| ISSN | 0031-1820 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/18255 | |
| Language | eng | pt_BR |
| Publisher | Cambridge University Press | pt_BR |
| Rights | restricted access | pt_BR |
| Subject in Portuguese | Leishmaniose visceral | pt_BR |
| Subject in Portuguese | infecçoes assintomaticas | pt_BR |
| Title | Leishmania infantum: illness, transmission profile and risk factors for asymptomatic infection in an endemic metropolis in Brazil | pt_BR |
| Type | Article | |
| DOI | 10.1017/S0031182016002134 | |
| Abstract | To evaluate the distribution of asymptomatic infection by Leishmania infantum in a metropolis in Brazil with different relative risks (RRs) for disease and risk factors associated with the infection, an ecological study was conducted using a Bayesian approach to estimate the RR of human visceral leishmaniasis (HVL) based on cases between 2008 and 2011. The areas were categorized and selected according to disease incidence: low (area-1), medium (area-2) and high (area-3). Cross-sectional study enrolling 935 children was used to estimate the prevalence of infection by L. infantum. Volunteers from these three areas were tested for L. infantum infection by ELISA (rK39 and soluble antigens). Infection prevalence rates were estimated and compared with the RR of disease. Multilevel logistic regression model evaluated the relationship between infection and the analysed variables. The RR of HVL was distributed heterogeneously in the municipality. The infection prevalence rates were: 34•9% in area-1; 29•3% in area-2; and 33•6% in area-3, with no significant differences between these areas. The variables ‘Presence of backyards in the neighbourhood’ and ‘Younger children’ were associated with L. infantum infection. We conclude that infection by L. infantum affects a significant proportion of the infant population regardless of the RR of disease | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Parasitologia. Laboratório de Epidemiologia de Doenças Infecciosas e Parasitárias. Belo Horizonte, MG, Brazil. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Parasitologia. Laboratório de Epidemiologia de Doenças Infecciosas e Parasitárias. Belo Horizonte, MG, Brazil. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Exatas. Departamento de Estatística. Belo Horizonte, MG, Brazil. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Parasitologia. Laboratório de Epidemiologia de Doenças Infecciosas e Parasitárias. Belo Horizonte, MG, Brazil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Pesquisas Clínicas. Belo Horizonte, MG, Brazil. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Parasitologia. Laboratório de Epidemiologia de Doenças Infecciosas e Parasitárias. Belo Horizonte, MG, Brazil. | pt_BR |
| Affilliation | Ministério da Saúde. Brasilia, DF, Brazil. | pt_BR |
| Affilliation | Prefeitura de Belo Horizonte. Secretaria Municipal de Saúde. Belo Horizonte, MG, Brazil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Pesquisas Clínicas. Belo Horizonte, MG, Brazil. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Parasitologia. Laboratório de Epidemiologia de Doenças Infecciosas e Parasitárias. Belo Horizonte, MG, Brazil. | pt_BR |
| Subject | visceral leishmaniasis | pt_BR |
| Subject | asymptomatic infection | pt_BR |
| Subject | infection | pt_BR |
| Subject | relative risk | pt_BR |
| Embargo date | 2035-01-01 | |
