| Author | Góes, V. C. | |
| Author | Neves, R. H. | |
| Author | Alencar, A. C. M. B. | |
| Author | Oliveira, A. V. | |
| Author | Gomes, D. C. | |
| Author | Silva, J. R. Machado | |
| Access date | 2017-04-06T15:26:23Z | |
| Available date | 2017-04-06T15:26:23Z | |
| Document date | 2012 | |
| Citation | GÓES, V. C. et al. Effects of high-fat chow on heart tissue in acute and chronic experimental murine schistosomiasis mansoni. Parasitology, v.139, p.1462-1470, 2012. | pt_BR |
| ISSN | 0031-1820 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/18292 | |
| Language | eng | pt_BR |
| Publisher | Cambridge University Press | pt_BR |
| Rights | restricted access | pt_BR |
| Subject in Portuguese | Esquistossomose mansoni | pt_BR |
| Subject in Portuguese | Coração | pt_BR |
| Subject in Portuguese | Histopatologia | pt_BR |
| Subject in Portuguese | Estereologia | pt_BR |
| Subject in Portuguese | Alto teor de gordura na comida | pt_BR |
| Title | Effects of high-fat chow on heart tissue in acute and chronic experimental murine schistosomiasis mansoni | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1017/S0031182012000807 | |
| Abstract | This study aimed to investigate myocardial injuries in mice infected with Schistosoma mansoni and fed a high-fat chow. Sections of myocardial tissue from S. mansoni-infected mice, and controls that had been killed 9 and 17 weeks post-infection, were stained with H&E and Picrosirius red. Histopathological examination, stereological design-based method (optical disector) and morphometry (vessels, cardiomyocytes and an amount of collagen) were used. Data were analysed using two-way ANOVA. Regardless of time of infection, myocardial tissue from the infected mice fed high-fat chow showed myocarditis characterized by a higher number of inflammatory foci, several areas displaying coagulation of cardiac fibres, a greater loss of cardiomyocytes and fibroblast proliferation than in the standard chow control. Comparing infected mice from acute and chronic infections, a higher cardiomyocyte hyperplasia (P < 0·0001) and higher amounts of collagen (P < 0·05) were observed than in standard chow control. In addition, all animals fed high-fat chow showed lower numerical density and total number of cardiomyocytes (P < 0·05), thicker vessel walls and narrowed luminal intramyocardial vessels (P > 0·05) than in the standard chow control. Altogether the data supported the view that a double burden has a synergistic deleterious effect on the myocardial tissue. | pt_BR |
| Affilliation | Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Departamento de Microbiologia, Imunologia e Parasitologia. Laboratório de Helmintologia Romero Lascasas Porto. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Helmintos Parasitos de Vertebrados. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Departamento de Microbiologia, Imunologia e Parasitologia. Laboratório de Helmintologia Romero Lascasas Porto. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Departamento de Patologia e Laboratórios. Disciplina de Anatomia Patológica. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Helmintos Parasitos de Vertebrados. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Departamento de Microbiologia, Imunologia e Parasitologia. Laboratório de Helmintologia Romero Lascasas Porto. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | schistosomiasis mansoni | pt_BR |
| Subject | heart | pt_BR |
| Subject | high-fat chow | pt_BR |
| Subject | histopathology | pt_BR |
| Subject | stereology | pt_BR |
| e-ISSN | 1469-8161 | |
| Embargo date | 2030-01-01 | |
