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AutorSilva, Marcelo Costa
AutorSilva, Carolina Alves Costa
AutorMachado, Gustavo Uzêda
AutorAtta, Ajax Mercês
AutorFreire, Songeli M
AutorCarvalho Filho, Edgar Marcelino
AutorSchinoni, Maria Isabel
AutorParaná, Raymundo
Fecha de acceso2017-04-07T13:05:39Z
Fecha de disponibilización2017-04-07T13:05:39Z
Fecha de publicación2016
ReferenciaSILVA, M. C. et al. HCV/HTLV coinfection: Does HTLV-1 interfere in the natural history of HCV-related diseases? Journal of Medical Virology, v. 88, p. 1967–1972, 2016.pt_BR
ISSN0146-6615pt_BR
URIhttps://www.arca.fiocruz.br/handle/icict/18305
DescripciónEdgard Marcelino de Carvalho Filho. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. "Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento".pt_BR
PromociónCNPq (Universal); Grant sponsor: LIA Projectpt_BR
Idiomaengpt_BR
EditorWileypt_BR
Derechos de autoropen accesspt_BR
Palabras clave en PortuguésCitocinaspt_BR
Palabras clave en PortuguésEpidemiologiapt_BR
Palabras clave en PortuguésVírus da hepatite Cpt_BR
Palabras clave en PortuguésVírus T-linfotrópico do tipo 1pt_BR
Palabras clave en PortuguésHCVpt_BR
TítuloHCV/HTLV coinfection: Does HTLV-1 interfere in the natural history of HCV-related diseases?pt_BR
Tipo del documentoArticlept_BR
DOI10.1002/jmv.24538
Resumen en InglésHepatitis C virus (HCV) and human T-lymphotropic virus type 1 (HTLV-1) coinfection occurs in many regions. However, few studies have focused on the natural history of HCV-induced liver disease in coinfected patients. To describe the clinical, epidemiological, and histopathological aspects of HTLV-1/HCV coinfection in Brazil. A cross-sectional study with 23 patients coinfected with HCV/HTLV. The control groups consisted of 21 patients monoinfected with HCV and 20 patients monoinfected with HTLV-1. The cytokine profiles (Th1 and Th2 cell responses), clinical, laboratory features, and histopathological aspects were examined. The control group for cytokine analysis validation consisted of patients monoinfected with HTLV, and a fourth group consisted of healthy blood donors. No anthropometric differences present between the three infected groups. We observed higher serum concentrations of IFN-γ in patients coinfected with HCV/HTLV-1 than those in HCV monoinfected patients. The HCV/HTLV-1 coinfected group also exhibited a higher degree of liver steatosis than the HCV monoinfected patients. Results suggest that HCV/HTLV-1 coinfection may result in a different pattern of HCV infection due to the immunologic disorders likely associated with HTLV-1, but there is no clear evidence of the HTLV role in the natural history of HCV infection.pt_BR
AfiliaciónFederal University of Bahia. Department of Hepatology. Salvador, BA, Brazilpt_BR
AfiliaciónFederal University of Bahia. Department of Hepatology. Salvador, BA, Brazilpt_BR
AfiliaciónFederal University of Bahia. Department of Hepatology. Salvador, BA, Brazilpt_BR
AfiliaciónFederal University of Bahia. Clinical and Toxicological Analysis. Salvador, BA, Brazilpt_BR
AfiliaciónFederal University of Bahia. Immunology Laboratory of the Health Science Institute. Salvador, BA, Brazilpt_BR
AfiliaciónFederal University of Bahia. Immunology Service of the University Hospital Professor Edgar Santos. Salvador, BA, Brazilpt_BR
AfiliaciónFederal University of Bahia. Hepatology Center of the University Hospital Professor Edgar Santos. Salvador, BA, Brazilpt_BR
AfiliaciónFederal University of Bahia. Hepatology Center of the University Hospital Professor Edgar Santos. Salvador, BA, Brazilpt_BR
Palavras clave en InglêsCytokinespt_BR
Palavras clave en InglêsEpidemiologypt_BR
Palavras clave en InglêsHepatitis C viruspt_BR
Palavras clave en InglêsT-lymphotropic virus type 1pt_BR
Palavras clave en InglêsHCVpt_BR


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