| Author | Queiroz, Cleriston Farias | |
| Author | Lemos, Antonio Carlos Moreira | |
| Author | Bastos, Maria de Lourdes Santana | |
| Author | Neves, Margarida Célia Lima Costa | |
| Author | Camelier, Aquiles Assunção | |
| Author | Carvalho, Natália Barbosa | |
| Author | Carvalho Filho, Edgar Marcelino | |
| Access date | 2017-04-07T17:24:27Z | |
| Available date | 2017-04-07T17:24:27Z | |
| Document date | 2016 | |
| Citation | QUEIROZ, C. F. et al. Inflammatory and immunological profiles in patients with COPD: relationship with FEV 1 reversibility. Jornal Brasileiro de Pneumologia, v. 42, n. 4, p. 241-247, 2016. | pt_BR |
| ISSN | 1806-3713 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/18317 | |
| Description | Antonio Carlos Moreira Lemos. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. | pt_BR |
| Language | eng | pt_BR |
| Publisher | Sociedade Brasileira de Pneumologia e Tisiologia | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Doença pulmonar, obstrutiva crônica | pt_BR |
| Subject in Portuguese | Citocinas | pt_BR |
| Subject in Portuguese | Quimiocinas | pt_BR |
| Subject in Portuguese | Eosinófilos | pt_BR |
| Subject in Portuguese | Escarro/citologia | pt_BR |
| Subject in Portuguese | Volume expiratório forçado | pt_BR |
| Title | Inflammatory and immunological profiles in patients with COPD: relationship with FEV 1 reversibility | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1590/S1806-37562015000000122 | |
| Abstract | To determine whether COPD severity correlates with sputum cell counts, atopy, and asthma. Methods: This was a cross-sectional study involving 37 patients
with COPD and 22 healthy subjects with normal lung function (controls). Sputum cell
counts were determined by microscopy after centrifugation of samples. Skin prick tests
were performed, and serum cytokines were determined by ELISA. Results: Patients
were stratified by bronchodilator response: a non-reversible airflow limitation (nonRAL)
group comprised 24 patients showing no significant post-bronchodilator change in
FEV1; and a partially reversible airflow limitation (partialRAL) group comprised 13 patients
showing FEV1 reversibility (post-bronchodilator FEV1 increase ≥ 12%). The proportion
of eosinophils in sputum was higher in the partialRAL group than in the nonRAL group (p
< 0.01), and there was an inverse correlation between the proportion of eosinophils
and FEV1 (p < 0.05). However, none of the patients had a history of asthma and skin
prick test results did not differ between the two groups. In the patient sputum samples,
neutrophils predominated. Serum levels of TNF, IL-6, IL-8, and RANTES (CCL5) were
higher in patients than in controls (p < 0.001) but did not differ between the two patient
groups. Conclusions: COPD patients with partial FEV1 reversibility appear to have higher
sputum eosinophil counts and greater airway hyperresponsiveness than do those with
no FEV1 reversibility. However, we found that COPD severity did not correlate with atopy
or with the cytokine profile. | pt_BR |
| Affilliation | Universidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Serviço de Pneumologia. Ambulatório Magalhães Neto. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Serviço de Pneumologia. Ambulatório Magalhães Neto. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Serviço de Pneumologia. Ambulatório Magalhães Neto. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Serviço de Pneumologia. Ambulatório Magalhães Neto. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade do Estado da Bahia. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil | pt_BR |
| Subject | Pulmonary disease, chronic obstructive | pt_BR |
| Subject | Cytokines | pt_BR |
| Subject | Chemokines | pt_BR |
| Subject | Eosinophils | pt_BR |
| Subject | Sputum/cytology | pt_BR |
| Subject | Forced expiratory volume | pt_BR |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
