| Author | Lima Junior, Josué da Costa | |
| Author | Silva, Rodrigo Nunes Rodrigues da | |
| Author | Pereira, Virgínia Araújo | |
| Author | Storer, Fábio Luiz | |
| Author | Silva, Daiana de Souza Perce da | |
| Author | Fabrino, Daniela Leite | |
| Author | Santos, Fátima | |
| Author | Banic, Dalma Maria | |
| Author | Ferreira, Joseli de Oliveira | |
| Access date | 2017-04-11T12:18:05Z | |
| Available date | 2017-04-11T12:18:05Z | |
| Document date | 2012 | |
| Citation | LIMA JUNIOR, Josué da Costa; et al. Cells and mediators of inflammation (C-reactive protein, nitric oxide, platelets and neutrophils) in the acute and convalescent phases of uncomplicated Plasmodium vivax and Plasmodium falciparum infection. Mem Inst Oswaldo Cruz, v.107, n.8, p.1035-1041, Dec. 2012. | pt_BR |
| ISSN | 0074-0276 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/18362 | |
| Language | eng | pt_BR |
| Publisher | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Malária | pt_BR |
| Subject in Portuguese | proteína C-reativa | pt_BR |
| Subject in Portuguese | óxido nítrico | pt_BR |
| Subject in Portuguese | Neutrófilos de banda | pt_BR |
| Title | Cells and mediators of inflammation (C-reactive protein, nitric oxide, platelets and neutrophils) in the acute and convalescent phases of uncomplicated Plasmodium vivax and Plasmodium falciparum infection | pt_BR |
| Type | Article | |
| Abstract | The haematological changes and release of soluble mediators, particularly C-reactive protein (CRP) and nitric oxide (NO), during uncomplicated malaria have not been well studied, especially in Brazilian areas in which the disease is endemic. Therefore, the present study examined these factors in acute (day 0) and convalescent phase (day 15) patients infected with Plasmodium falciparum and Plasmodium vivax malaria in the Brazilian Amazon. Haematologic parameters were measured using automated cell counting, CRP levels were measured with ELISA and NO plasma levels were measured by the Griess reaction. Our data indicate that individuals with uncomplicated P. vivax and P. falciparum infection presented similar inflammatory profiles with respect to white blood cells, with high band cell production and a considerable degree of thrombocytopaenia during the acute phase of infection. Higher CRP levels were detected in acute P. vivax infection than in acute P. falciparum infection, while higher NO was detected in patients with acute and convalescent P. falciparum infections. Although changes in these mediators cannot predict malaria infection, the haematological aspects associated with malaria infection, especially the roles of platelets and band cells, need to be investigated further. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ. Brasil / Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ. Brasil | pt_BR |
| Affilliation | Faculdade São Lucas. Porto Velho, RO, Brasil. | pt_BR |
| Affilliation | Universidade Federal de São João Del Rei. Departamento de Química, Biotecnologia e Engenharia de Bioprocessos. Laboratório de Biotecnologia. Ouro Branco, MG, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Simulídeos e Oncocercose. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Laboratório Central. Departamento de Entomologia. Porto Velho, RO, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Simulídeos e Oncocercose. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Subject | malaria | pt_BR |
| Subject | C-reactive protein | pt_BR |
| Subject | nitric oxide | pt_BR |
| Subject | band neutrophils | pt_BR |
| e-ISSN | 1678-8060 | |
