| Author | Machado, Marcus Paulo Ribeiro | |
| Author | Rocha, Aletheia Moraes | |
| Author | Oliveira, Lucas Felipe de | |
| Author | Cuba, Marília Beatriz de | |
| Author | Loss, Igor de Oliveira | |
| Author | Castellano, Lucio Roberto | |
| Author | Silva, Marcus Vinicius | |
| Author | Machado, Juliana Reis | |
| Author | Nascentes, Gabriel Antonio Nogueira | |
| Author | Paiva, Luciano Henrique | |
| Author | Savino, Wilson | |
| Author | Junior, Virmondes Rodrigues | |
| Author | Brum, Patricia Chakur | |
| Author | Prado, Vania Ferreira | |
| Author | Prado, Marco Antonio Maximo | |
| Author | Silva, Eliane Lages | |
| Author | Montano, Nicola | |
| Author | Ramirez, Luis Eduardo | |
| Author | Silva, Valdo Jose Dias da | |
| Access date | 2017-04-20T13:10:43Z | |
| Available date | 2017-04-20T13:10:43Z | |
| Document date | 2012 | |
| Citation | MACHADO, Marcus Paulo Ribeiro; et al. Autonomic nervous system modulation affects the inflammatory immune response in mice with acute Chagas disease. Exp Physiol, v.97. n.11, p 1186–1202, 2012. | pt_BR |
| ISSN | 0958-0670 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/18589 | |
| Language | eng | pt_BR |
| Publisher | Wiley | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Doença de Chagas | pt_BR |
| Subject in Portuguese | Ratos | pt_BR |
| Subject in Portuguese | Sstema nervoso autônomo | pt_BR |
| Subject in Portuguese | Resposta imunológica inflamatória | pt_BR |
| Subject in Portuguese | Fase aguda | pt_BR |
| Title | Autonomic nervous system modulation affects the inflammatory immune response in mice with acute Chagas disease | pt_BR |
| Type | Article | |
| DOI | 10.1113/expphysiol.2012.066431 | |
| Abstract | The aim of the present study was to evaluate the effects of changes to the autonomic nervous system in mice during the acute phase of Chagas disease, which is an infection caused by the parasite Trypanosoma cruzi. The following types of mice were inoculated with T. cruzi (CHG): wild-type (WT) and vesicular acetylcholine transporter knockdown (KDVAChT) C57BL/6j mice; wild-type non-treated (NT) FVB mice; FVB mice treated with pyridostigmine bromide (PYR) or salbutamol (SALB); and β(2)-adrenergic receptor knockout (KOβ2) FVB mice. During infection and at 18-21 days after infection (acute phase), the survival curves, parasitaemia, electrocardiograms, heart rate variability, autonomic tonus and histopathology of the animals were evaluated. Negative control groups were matched for age, genetic background and treatment. The KDVAChT-CHG mice exhibited a significant shift in the electrocardiographic, autonomic and histopathological profiles towards a greater inflammatory immune response that was associated with a reduction in blood and tissue parasitism. In contrast, the CHG-PYR mice manifested reduced myocardial inflammation and lower blood and tissue parasitism. Similar results were observed in CHG-SALB animals. Unexpectedly, the KOβ2-CHG mice exhibited less myocardial inflammation and higher blood and tissue parasitism, which were associated with reduced mortality. These findings could have been due to the increase in vagal tone observed in the KOβ2 mice, which rendered them more similar to the CHG-PYR animals. In conclusion, our results indicate a marked immunomodulatory role for the parasympathetic and sympathetic autonomic nervous systems, which inhibit both the inflammatory immune response and parasite clearance during the acute phase of experimental Chagas heart disease in mice. | pt_BR |
| Affilliation | Universidade Federal do Triângulo Mineiro. Instituto de Ciências Biológicas. Uberaba, MG, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Triângulo Mineiro. Instituto de Ciências Biológicas. Uberaba, MG, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Triângulo Mineiro. Instituto de Ciências Biológicas. Uberaba, MG, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Triângulo Mineiro. Instituto de Ciências Biológicas. Uberaba, MG, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Triângulo Mineiro. Instituto de Ciências Biológicas. Uberaba, MG, Brasil. | pt_BR |
| Affilliation | Universidade Federal da Paraíba. João Pessoa, PB, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Triângulo Mineiro. Instituto de Ciências Biológicas. Uberaba, MG, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Triângulo Mineiro. Instituto de Ciências Biológicas. Uberaba, MG, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Triângulo Mineiro. Instituto de Ciências Biológicas. Uberaba, MG, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Triângulo Mineiro. Instituto de Ciências Biológicas. Uberaba, MG, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Universidade Federal do Triângulo Mineiro. Instituto de Ciências Biológicas. Uberaba, MG, Brasil. | pt_BR |
| Affilliation | Universidade de São Paulo. Escola de Educação Física e Esportes. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | University of Western Ontario. Schulich School of Medicine & Dentistry. Robarts Research Institute. Molecular Brain Research Group. Ontario, Canada. | pt_BR |
| Affilliation | University of Western Ontario. Schulich School of Medicine & Dentistry. Robarts Research Institute. Molecular Brain Research Group. Ontario, Canada. | pt_BR |
| Affilliation | Universidade Federal do Triângulo Mineiro. Instituto de Ciências Biológicas. Uberaba, MG, Brasil. | pt_BR |
| Affilliation | University of Milan. Department of Clinical Sciences. Internal Medicine II, L. Sacco Hospital. Milano, Italy. | pt_BR |
| Affilliation | Universidade Federal do Triângulo Mineiro. Instituto de Ciências Biológicas. Uberaba, MG, Brasil. | pt_BR |
| Subject | Autonomic nervous system | pt_BR |
| Subject | inflammatory immune response | pt_BR |
| Subject | mice | pt_BR |
| Subject | Chagas Disease | pt_BR |
| Subject | acute phase | pt_BR |
| e-ISSN | 1469-445X | |
| Embargo date | 2030-01-01 | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
