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Título: Semaphorins and neuropilins: new players in the neuroendocrine control of the intrathymic T-cell migration in humans
Autor : Cruz, Daniella Arêas Mendes da
Lacerda, Leandra Linhares
Smaniotto, Salete
Dardenne, Mireille
Savino, Wilson
Afiliación: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil.
Universidade Federal de Alagoas. Departamento de Morfologia. Maceió, AL, Brasil
Paris Descartes University. CNRS UMR8147. Paris, France.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil.
Resumen: Cell migration is a key event for proper intrathymic T-cell differentiation, and several ligand-receptor interactions contribute to the well-co ordinated movement of developing thymocytes within the thymic lobules. Herein we summarize recent data that place semaphorin 3A (Sema3A) and its receptor neuropilin 1 (NRP1) as further players in the physiological process of cell migration in the human thymus. These molecules, as well as class A plexins (necessary for the intracellular signalling transduction triggered by Sema3A-NRP1 ligation), are constitutively expressed by both developing thymocytes and components of the thymic microenvironment, including epithelial and dendritic cells. Functionally, Sema3A decreases the adhesion of human thymocytes on thymic epithelial cell monolayers and exerts per se a dose-dependent chemorepulsive effect on human thymocytes. Moreover, Sema3A inhibits chemoattractant migratory responses induced by other ligands, including fibronectin, laminin and CXCL12 (chemokine CXC motif ligand 12). These data should be placed in the context of the concept that migration of developing T cells is a multivectorial system, in which the resulting migration vector derives from a balance of several simultaneous and/or sequential ligand-receptor pair interactions. Accordingly, semaphorins and neuropilins can be considered as further players in the system.
Palabras clave en ingles: intrathymic T-cell migration
Semaphorins
neuropilins
neuroendocrine control
Palabras clave en portugues: Migração intratímica de células T
Controle neuroendócrino
Neuropilinas
Semaforinas
Fecha de publicación: 2012
Editorial : Wiley
Referencia: CRUZ, Daniella Arêas Mendes da; et al. Semaphorins and neuropilins: new players in the neuroendocrine control of the intrathymic T-cell migration in humans. Esp. Psysiol, v.97, n.11, p.1146-1150, 2012.
DOI: 10.1113/expphysiol.2011.061515
ISSN : 0958-0670
Derechos de autor: restricted access
Aparece en las colecciones: IOC - Artigos de Periódicos

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