| Author | Antas, Paulo | |
| Author | Holland, Steven | |
| Author | Sterling, Timothy | |
| Access date | 2017-04-27T15:15:40Z | |
| Available date | 2017-04-27T15:15:40Z | |
| Document date | 2012 | |
| Citation | ANTAS, Paulo: HOLLAND, Steven: STERLING, Timothy. Abnormal spontaneous interleukin 8 receptor expression: a brief report of two cases. Revista da Sociedade Brasileira de Medicina Tropical, v.45, n.1, p.134-137, jan-fev, 2012. | pt_BR |
| ISSN | 0037-8682 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/18688 | |
| Language | eng | pt_BR |
| Publisher | Sociedade Brasileira de Medicina Tropical | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Interleucina-8 | pt_BR |
| Subject in Portuguese | Receptores | pt_BR |
| Subject in Portuguese | Linfócitos | pt_BR |
| Subject in Portuguese | Citocinas | pt_BR |
| Title | Abnormal spontaneous interleukin 8 receptor expression: a brief report of two cases | pt_BR |
| Alternative title | Expressão espontânea anômala do receptor de interleucina 8: um breve relato de dois casos | pt_BR |
| Type | Article | |
| Abstract | Interleukin 8 (CXCL8) is an autocrine chemokine specific for the
chemoattraction and activation of granulocytes, NKT cells and T
lymphocytes. Patients with tuberculosis and latent Mycobacterium tuberculosis
infection were assessed for the spontaneous expression of CXCR1 (CD128)
and CXCR2 on lymphocytes and monocytes. Compared with ex vivo profiles,
increased spontaneous CXCR2 expression and normal CXCR1 expression
were found on lymphocytes in two out of 59 individuals. Monocytes showed
normal ex vivo profiles for both receptors. After stimulation with purified
protein derivative, the in vitro levels of CXCL8 were below the median levels
of all patients with prior tuberculosis. Spontaneous CXCR2 modulation did
not cause notable variation in the in vitro levels of CXCL8. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Clínica. Rio de Janeiro, RJ. Brasil / National Institute of Health. Laboratory of Clinical Infectious . Bethesda, MA, USA / Vanderbilt University School of Medicine. Department of Medicine. Division of Infectious Diseases. Nasville, TN, USA. | pt_BR |
| Affilliation | National Institutes of Health. Laboratory of Clinical Infectious Diseases. Bethesda, MA, USA. | pt_BR |
| Affilliation | Vanderbilt University School of Medicine. Department of Medicine. Division of Infectious Diseases. Nasville, TN, USA. / Vanderbilt University School of Medicine. Department of Medicine. Center for Health Services Research. Nasville, TN, USA. | pt_BR |
| Subject | Interleukin 8 receptor | pt_BR |
| Subject | Lymphocytes | pt_BR |
| Subject | Cytokines | pt_BR |
| e-ISSN | 1678-9849 | |
