Author | Cunha Junior, Edézio Ferreira | |
Author | Andrade Neto, Valter Viana | |
Author | Lima, Marta Lopes | |
Author | Silva, Thais Alves da Costa | |
Author | Galisteo Junior, Andres J. | |
Author | Abengózar, Maria A. | |
Author | Barbas, Coral | |
Author | Rivas, Luis | |
Author | Amaral, Elmo Eduardo Almeida | |
Author | Tempone, Andre Gustavo | |
Author | Santos, Eduardo Caio Torres | |
Access date | 2017-05-04T12:14:58Z | |
Available date | 2017-05-04T12:14:58Z | |
Document date | 2017 | |
Citation | CUNHA JUNIOR, Edézio Ferreira; et al. Cyclobenzaprine Raises ROS Levels in Leishmania infantum and Reduces Parasite Burden in Infected Mice. PLoS Negl Trop Dis, v.11, n.1, e0005281, 11p, Jan. 2017. | pt_BR |
ISSN | 1935-2727 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/18728 | |
Language | eng | pt_BR |
Publisher | Public Library of Science | pt_BR |
Rights | open access | |
Subject in Portuguese | Lieshmaniose | pt_BR |
Subject in Portuguese | Cyclobenzaprine | pt_BR |
Subject in Portuguese | Terapêutica | pt_BR |
Title | Cyclobenzaprine Raises ROS Levels in Leishmania infantum and Reduces Parasite Burden in Infected Mice | pt_BR |
Type | Article | |
DOI | 10.1371/journal.pntd.0005281 | |
Abstract | The leishmanicidal action of tricyclic antidepressants has been studied and evidences have pointed that their action is linked to inhibition of trypanothione reductase, a key enzyme in the redox metabolism of pathogenic trypanosomes. Cyclobenzaprine (CBP) is a tricyclic structurally related to the antidepressant amitriptyline, differing only by the presence of a double bond in the central ring. This paper describes the effect of CBP in experimental visceral leishmaniasis, its inhibitory effect in trypanothione reductase and the potential immunomodulatory activity. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanosomatídeos. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanosomatídeos. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Universidade de São Paulo. Instituto de Medicina Tropical. São Paulo, SP, Brasil / Instituto Adolfo Lutz. Centro de Parasitologia e Micologia. São Paulo, SP, Brasil. | pt_BR |
Affilliation | Instituto Adolfo Lutz. Centro de Parasitologia e Micologia. São Paulo, SP, Brasil. | pt_BR |
Affilliation | Universidade de São Paulo. Instituto de Medicina Tropical. São Paulo, SP, Brasil. | pt_BR |
Affilliation | Centro de Investigaciones BioloÂgicas (CSIC). Unidad Asociada Interacciones, Metabolismo y Bioanálisis CSIC-CEU. Madrid, Spain. | pt_BR |
Affilliation | Universidad CEU San Pablo. Faculty of Pharmacy. Center for Metabolomics and Bioanalysis (CEMBIO. Madrid, Spain. | pt_BR |
Affilliation | Centro de Investigaciones BioloÂgicas (CSIC). Unidad Asociada Interacciones, Metabolismo y Bioanálisis CSIC-CEU. Madrid, Spain. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanosomatídeos. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Instituto Adolfo Lutz. Centro de Parasitologia e Micologia. São Paulo, SP, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanosomatídeos. Rio de Janeiro, RJ. Brasil. | pt_BR |
Subject | Cyclobenzaprine | pt_BR |
Subject | therapeutic | pt_BR |
Subject | visceral leishmaniasis | pt_BR |
e-ISSN | 1935-2735 | |