Author | Carvalho, Paulo C. | |
Author | Fischer, Juliana S. G. | |
Author | Xu, Tao | |
Author | Cociorva, Daniel | |
Author | Balbuena, Tiago S. | |
Author | Valente, Richard H. | |
Author | Perales, Jonas | |
Author | Yates, John R. | |
Author | Barbosa, Valmir C. | |
Access date | 2017-05-04T15:29:57Z | |
Available date | 2017-05-04T15:29:57Z | |
Document date | 2012 | |
Citation | CARVALHO, Paulo C. et al. Search engine processor: Filtering and organizing peptide spectrum matches. Proteomics, v.12, p.944-949, 2012. | pt_BR |
ISSN | 1615-9853 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/18755 | |
Language | eng | pt_BR |
Publisher | Wiley | pt_BR |
Rights | restricted access | |
Subject in Portuguese | Bioinformática | pt_BR |
Subject in Portuguese | Filtragem | pt_BR |
Subject in Portuguese | Qualidade | pt_BR |
Subject in Portuguese | Compartilhamento | pt_BR |
Subject in Portuguese | Avaliação comparativa | pt_BR |
Title | Search engine processor: Filtering and organizing peptide spectrum matches | pt_BR |
Type | Article | |
DOI | 10.1002/pmic.201100529 | |
Abstract | The search engine processor (SEPro) is a tool for filtering, organizing, sharing, and displaying peptide spectrum matches. It employs a novel three-tier Bayesian approach that uses layers of spectrum, peptide, and protein logic to lead the data to converge to a single list of reliable protein identifications. SEPro is integrated into the PatternLab for proteomics environment, where an arsenal of tools for analyzing shotgun proteomic data is provided. By using the semi-labeled decoy approach for benchmarking, we show that SEPro significantly outperforms a commercially available competitor. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Toxinologia. Rio de Janeiro, RJ. Brasil / Fundação Oswaldo Cruz. Instituto Carlos Chagas. Paraná, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Toxinologia. Rio de Janeiro, RJ. Brasil / Fundação Oswaldo Cruz. Instituto Carlos Chagas. Paraná, Brasil | pt_BR |
Affilliation | The Scripps Research Institute. Department of Chemical Physiology. La Jolla, CA, USA. | pt_BR |
Affilliation | The Scripps Research Institute. Department of Chemical Physiology. La Jolla, CA, USA. | pt_BR |
Affilliation | University of Missouri. Department of Biochemistry. Columbia, MO, USA. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Toxinologia. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Toxinologia. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | The Scripps Research Institute. Department of Chemical Physiology. La Jolla, CA, USA. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. COPPE. Programa de Engenharia de Sistemas e Ciência da Computação. Rio de Janeiro, RJ, Brasil.l | pt_BR |
Subject | Bioinformatics | pt_BR |
Subject | Filtering | pt_BR |
Subject | Quality | pt_BR |
Subject | Semi-labeled decoy approach | pt_BR |
Subject | Sharing | pt_BR |
Subject | Shotgun proteomics | pt_BR |
e-ISSN | 1615-9861 | |
Embargo date | 2030-01-01 | |