| Author | Aragao, M. F. V. V. | |
| Author | Brainer-Lima, A. M. | |
| Author | Holanda, A. C. | |
| Author | van der Linden, V. | |
| Author | Vasco Aragão, L. | |
| Author | Silva, M. L. M. | |
| Author | Sarteschi, C. | |
| Author | Petribu, N. C. L. | |
| Author | Valença, M. M. | |
| Access date | 2017-05-05T18:09:33Z | |
| Available date | 2017-05-05T18:09:33Z | |
| Document date | 2017 | |
| Citation | ARAGAO, M. F. V. V. et al. Spectrum of Spinal Cord, Spinal Root, and Brain MRI Abnormalities in Congenital Zika Syndrome with and without Arthrogryposis. American Journal of Neuroradiology, v. 38, n. 5, p. 1045–1053, maio 2017. | |
| ISSN | 1936-959X | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/18772 | |
| Language | eng | pt_BR |
| Rights | restricted access | pt_BR |
| Title | Spectrum of Spinal Cord, Spinal Root, and Brain MRI Abnormalities in Congenital Zika Syndrome with and without Arthrogryposis | pt_BR |
| Type | Article | |
| DOI | 10.3174/ajnr.A5125 | pt_BR |
| Abstract | BACKGROUND AND PURPOSE: Arthrogryposis is among the malformations of congenital Zika syndrome. Similar to the brain, there
might exist a spectrum of spinal cord abnormalities. The purpose of this study was to explore and describe in detail the MR imaging
features found in the spinal cords, nerve roots, and brains of children with congenital Zika syndrome with and without
arthrogryposis.
MATERIALS AND METHODS: Twelve infants with congenital Zika syndrome (4 with arthrogryposis and 8 without) who had undergone
brain and spinal cord MR imaging were retrospectively selected. Qualitative and quantitative analyses were performed and compared
between groups.
RESULTS: At visual inspection, both groups showed reduced thoracic spinal cord thickness: 75% (6/8) of the group without arthrogryposis
and 100% (4/4) of the arthrogryposis group. However, the latter had the entire spinal cord reduced and more severely reduced conus
medullaris anterior roots (respectively, P .002 and .007). Quantitative differences were found for conus medullaris base and cervical and
lumbar intumescences diameters (respectively, P .008, .048, .008), with more prominent reduction in arthrogryposis. Periventricular
calcifications were more frequent in infants with arthrogryposis (P .018).
CONCLUSIONS: Most infants had some degree of spinal cord thickness reduction, predominant in the thoracic segment (without
arthrogryposis) or in the entire spinal cord (with arthrogryposis). The conus medullaris anterior roots were reduced in both groups
(thinner in arthrogryposis). A prominent anterior median fissure of the spinal cord was absent in infants without arthrogryposis. Brain
stem hypoplasia was present in all infants with arthrogryposis, periventricular calcifications, in the majority, and polymicrogyria was
absent. | |
| Affilliation | Centro Diagnostico Multimagem. Recife, PE, Brazil / Mauricio de Nassau University. Recife, PE, Brazil. | |
| Affilliation | PROCAPE. Recife, PE, Brazil / Mauricio de Nassau University. Recife, PE, Brazil. | |
| Affilliation | Federal University of Pernambuco. Recife, PE, Brazil. | |
| Affilliation | Association for Assistance of Disabled Children. Recife, PE, Brazil / Barão de Lucena Hospital. Recife, PE, Brazil. | |
| Affilliation | Prof. Fernando Figueira Integral Medicine Institute. Recife, PE, Brazil. | |
| Affilliation | Federal University of Pernambuco. Recife, PE, Brazil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil. | |
| Affilliation | Barão de Lucena Hospital. Recife, PE, Brasil. | |
| Affilliation | Federal University of Pernambuco. Recife, PE, Brasil. | |
| DeCS | Cérebro / patologia | |
| DeCS | Medula espinhal / patologia | |
| DeCS | Raízes do nervo espinhal / patologia | |
| DeCS | Zika a infecção pelo vírus / imagiologia de diagnóstico | |
| DeCS | Infecção pelo vírus Zika / patologia | |
