| Author | Losada-Barragán, Monica | |
| Author | Umaña-Pérez, Adriana | |
| Author | Cuervo-Escobar, Sergio | |
| Author | Berbert, Luiz Ricardo | |
| Author | Porrozzi, Renato | |
| Author | Morgado, Fernanda N. | |
| Author | Cruz, Daniella Arêas Mendes da | |
| Author | Savino, Wilson | |
| Author | Sánchez-Gómez, Myriam | |
| Author | Cuervo, Patricia | |
| Access date | 2017-05-06T14:50:06Z | |
| Available date | 2017-05-06T14:50:06Z | |
| Document date | 2017 | |
| Citation | LOSADA-BARRAGÁN, Monica et al. Protein malnutrition promotes dysregulation of molecules involved in T cell migration in the thymus of mice infected with Leishmania infantum. Scientific Reports, v. 7, p. 1-13, Apr. 2017. | pt_BR |
| ISSN | 2045-2322 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/18775 | |
| Description | Erratum: Protein malnutrition promotes dysregulation of molecules involved in T cell migration in the thymus of mice infected with Leishmania infantum Monica Losada-Barragán, Adriana Umaña-Pérez, Sergio Cuervo-Escobar, Luiz Ricardo Berbert, Renato Porrozzi, Fernanda N. Morgado, Daniella Areas Mendes-da-Cruz, Wilson Savino, Myriam Sánchez-Gómez & Patricia Cuervo Scientific Reports 7:45991; published online 11 April 2017; updated on 25 September 2017 In this Article, Figure 4 is incorrect. The correct Figure 4 appears below as Figure 1. The legend of Figure 4 was correct from the time of publication. | pt_BR |
| Language | eng | pt_BR |
| Publisher | Nature Publishing Group | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Timo | pt_BR |
| Subject in Portuguese | Leishmaniose visceral | pt_BR |
| Subject in Portuguese | Migração de células T | pt_BR |
| Subject in Portuguese | Carência de proteína | pt_BR |
| Subject in Portuguese | Leishmania infantum | pt_BR |
| Title | Protein malnutrition promotes dysregulation of molecules involved in T cell migration in the thymus of mice infected with Leishmania infantum | pt_BR |
| Type | Article | |
| DOI | 10.1038/srep45991 | |
| Abstract | Protein malnutrition, the most deleterious cause of malnutrition in developing countries, has been considered a primary risk factor for the development of clinical visceral leishmaniasis (VL). Protein malnutrition and infection with Leishmania infantum leads to lymphoid tissue disorganization, including changes in cellularity and lymphocyte subpopulations in the thymus and spleen. Here we report that protein malnutrition modifies thymic chemotactic factors by diminishing the CCL5, CXCL12, IGF1, CXCL9 and CXCL10 protein levels in infected animals. Nevertheless, T cells preserve their migratory capability, as they were able to migrate ex vivo in response to chemotactic stimuli, indicating that malnutrition may compromise the thymic microenvironment and alter in vivo thymocyte migration. Decrease in chemotactic factors protein levels was accompanied by an early increase in the parasite load of the spleen. These results suggest that the precondition of malnutrition is affecting the cell-mediated immune response to L. infantum by altering T cell migration and interfering with the capacity of protein-deprived animals to control parasite spreading and proliferation. Our data provide evidence for a disturbance of T lymphocyte migration involving both central and peripheral T-cells, which likely contribute to the pathophysiology of VL that occurs in malnourished individuals. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmaniose. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidad Nacional de Colombia. Sede Bogotá. Facultad de Ciencias. Departamento de Química. Grupo de Investigación en Hormonas. Bogotá, Colombia. | pt_BR |
| Affilliation | Universidad Nacional de Colombia. Sede Bogotá. Facultad de Ciencias. Departamento de Química. Grupo de Investigación en Hormonas. Bogotá, Colombia. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmaniose. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmaniose. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidad Nacional de Colombia. Sede Bogotá. Facultad de Ciencias. Departamento de Química. Grupo de Investigación en Hormonas. Bogotá, Colombia. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmaniose. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Leishmania infantum | pt_BR |
| Subject | Thymus | pt_BR |
| Subject | T cell migration | pt_BR |
| Subject | Protein malnutrition | pt_BR |
| Subject | Visceral leishmaniasis | pt_BR |
| e-ISSN | 2045-2322 | |
| xmlui.metadata.dc.subject.ods | 02 Fome zero e agricultura sustentável | |
