| Author | Vidal, Manuela Torres Andion | |
| Author | Lourenço, Sílvia Vanessa | |
| Author | Soares, Fernando Augusto | |
| Author | Gurgel, Clarissa Araújo | |
| Author | Studart, Eduardo José Bittencourt | |
| Author | Valverde, Ludmila de Faro | |
| Author | Araújo, Iguaracyra Barreto de Oliveira | |
| Author | Ramos, Eduardo Antônio Gonçalves | |
| Author | Xavier, Flávia Caló de Aquino | |
| Author | Santos, Jean Nunes dos | |
| Access date | 2017-05-08T17:26:00Z | |
| Available date | 2017-05-08T17:26:00Z | |
| Document date | 2016 | |
| Citation | VIDAL, M. T. A. et al. The sonic hedgehog signaling pathway contributes to the development of salivary gland neoplasms regardless of perineural infiltration. Tumor Biology, v. 37, p. 9587–9601, 2016. | pt_BR |
| ISSN | 1010-4283 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/18787 | |
| Language | eng | pt_BR |
| Publisher | Springer Verlag | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Tumores das glândulas salivares | pt_BR |
| Subject in Portuguese | Hedgehogproteins | pt_BR |
| Subject in Portuguese | STAT fatores de transcrição | pt_BR |
| Subject in Portuguese | Componente complexo de manutenção do minicromossoma 3 | pt_BR |
| Title | The sonic hedgehog signaling pathway contributes to the development of salivary gland neoplasms regardless of perineural infiltration | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1007/s13277-016-4841-4 | |
| Abstract | The pleomorphic adenoma (PA), mucoepidermoid carcinoma (MEC), and adenoid cystic carcinoma (ACC) are common tumors arising from salivary glands whose histopathology is heterogeneous. The sonic hedgehog signaling pathway (Hh) and signal transducer and activator of transcription 3 (STAT3) play important roles in cell proliferation, favoring tumor growth. The aim of this investigation was to study components of the Hh pathway, as well as STAT3 in salivary gland neoplasms in an attempt to add information about the biological characteristics of these neoplasms. We used 9 cases of PA, 17 cases of ACC, and 20 cases of MEC. Using immunohistochemistry, SHH, GLI1, SUFU, HHIP, and STAT3 were investigated. For comparative purposes, MCM3 (cellular proliferation marker) was also included. In PA, there was high expression of cytoplasmic SHH and SUFU and low expression of STAT3 and MCM3. In the ACC, there was high expression of GLI1, HHIP, and STAT3 and low expression of SHH, SUFU, and MCM3. In the MEC, we observed high expression of SHH, GLI1, SUFU, and HHIP and low expression of STAT3 and MCM3. There was a statistically significant difference between SHH (p = 0.0064), STAT3 (p = 0.0003), and MCM3 (p = 0.0257) when all tumors were compared and a higher expression in parenchyma for all tumors when stroma and parenchyma were compared (p < 0.05). These findings suggests a possible role of Hh pathway in the development and maintenance of the cytoarchitectural pattern of PA, ACC, and MEC, as well as the participation of STAT3 in the development of ACC, irrespective perineural infiltration. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | A.C. Camargo Cancer Center. São Paulo, SP, Brasil | pt_BR |
| Affilliation | A.C. Camargo Cancer Center. São Paulo, SP, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Federal University of Bahia. School of Medicine. Department of Pathology and Forensic Medicine. Salvador, BA, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Federal University of Bahia. School of Medicine. Department of Pathology and Forensic Medicine. Salvador, BA, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Federal University of Bahia. School of Dentistry. Laboratory of Oral Surgical Pathology. Salvador, BA, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Federal University of Bahia. School of Dentistry. Laboratory of Oral Surgical Pathology. Salvador, BA, Brazil / Universidade Federal da Bahia. Laboratório de Patologia Cirúrgica. Salvador, BA, Brasil | pt_BR |
| Subject | Salivary gland tumors | pt_BR |
| Subject | Hedgehogproteins | pt_BR |
| Subject | STAT transcription factors | pt_BR |
| Subject | Minichromosomemaintenance complex component 3 | pt_BR |
| DeCS | Tumores | pt_BR |
| DeCS | Glândulas salivares | pt_BR |
| DeCS | Proteinas Hedhehog | pt_BR |
| DeCS | Fatores de transcrição | pt_BR |
| DeCS | Componente 3 do complexo de manutenção do minicromossoma | pt_BR |
