| Author | Calvet, Claudia M. | |
| Author | Melo, Tatiana G. | |
| Author | Garzoni, Luciana R. | |
| Author | Oliveira, Francisco O. R. | |
| Author | Silva Neto, Dayse T. | |
| Author | N. S. L. Miereles, Maria | |
| Author | Pereira, Mirian C. S. | |
| Access date | 2017-05-09T16:45:02Z | |
| Available date | 2017-05-09T16:45:02Z | |
| Document date | 2012 | |
| Citation | CALVET, Claudia M. et al. Current understanding of theTrypanosoma cruzi–cardiomyocyte interaction. Frontiers in Immunology, Volume 2, Article 327, 8p, Oct. 2012. | pt_BR |
| ISSN | 1664-3224 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/18798 | |
| Language | eng | pt_BR |
| Publisher | Frontiers Media | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Trypanosoma cruzi, | pt_BR |
| Subject in Portuguese | Cardiomiócito | pt_BR |
| Subject in Portuguese | Reconhecimento de células | pt_BR |
| Subject in Portuguese | Endocitose | pt_BR |
| Subject in Portuguese | Junção celular | pt_BR |
| Subject in Portuguese | Matriz extracelular | pt_BR |
| Subject in Portuguese | Apoptose | pt_BR |
| Title | Current understanding of the Trypanosoma cruzi-cardiomyocyte interaction | pt_BR |
| Type | Article | |
| DOI | 10.3389/fimmu.2012.00327 | |
| Abstract | Trypanosoma cruzi, the etiological agent of Chagas disease, exhibits multiple strategies to ensure its establishment and persistence in the host. Although this parasite has the ability to infect different organs, heart impairment is the most frequent clinical manifestation of the disease. Advances in knowledge of T. cruzi-cardiomyocyte interactions have contributed to a better understanding of the biological events involved in the pathogenesis of Chagas disease. This brief review focuses on the current understanding of molecules involved in T. cruzi-cardiomyocyte recognition, the mechanism of invasion, and on the effect of intracellular development of T. cruzi on the structural organization and molecular response of the target cell. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Ultraestrutura Celular. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Ultraestrutura Celular. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Ultraestrutura Celular. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Ultraestrutura Celular. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Ultraestrutura Celular. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Ultraestrutura Celular. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Ultraestrutura Celular. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Subject | Trypanosoma cruzi | pt_BR |
| Subject | cardiomyocyte | pt_BR |
| Subject | cell recognition | pt_BR |
| Subject | endocytosis | pt_BR |
| Subject | cell junction | pt_BR |
| Subject | extracellular matrix | pt_BR |
| Subject | apoptosis | pt_BR |
