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EFFECT OF POLYMORPHISMS ON TGFB1 ON ALLERGIC ASTHMA AND HELMINTH INFECTION IN AN AFRICAN ADMIXED POPULATION
Polimorfismo
População
Helmintos
Infecções por Helmintos
Variação genética
Alergia
Author
Affilliation
Johns Hopkins University. Division of Allergy and Clinical Immunology. Baltimore, Maryland / Federal University of Bahia. Health Science Institute. Salvador, BA, Brazil
Federal University of Bahia. Health Science Institute. Salvador, BA, Brazil
Federal University of Bahia. Public Health Institute. Salvador, BA, Brazil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brazil
Federal University of Bahia. Health Science Institute. Salvador, BA, Brazil
London School of Hygiene and Tropical Medicine. London, England
Federal University of Bahia. Center of Excellence in Asthma. Salvador, BA, Brazil
Johns Hopkins University. Division of Allergy and Clinical Immunology. Baltimore, Maryland
Johns Hopkins University. Division of Allergy and Clinical Immunology. Baltimore, Maryland
Johns Hopkins University. Division of Allergy and Clinical Immunology. Baltimore, Maryland
Johns Hopkins University. Division of Allergy and Clinical Immunology. Baltimore, Maryland
Johns Hopkins University. Division of Allergy and Clinical Immunology. Baltimore, Maryland
Johns Hopkins University. Division of Allergy and Clinical Immunology. Baltimore, Maryland
Johns Hopkins University. Division of Allergy and Clinical Immunology. Baltimore, Maryland / University of Colorado Denver. Department of Medicine. Aurora, Colorado
Federal University of Bahia. Health Science Institute. Salvador, BA, Brazil
Federal University of Bahia. Public Health Institute. Salvador, BA, Brazil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brazil
Federal University of Bahia. Health Science Institute. Salvador, BA, Brazil
London School of Hygiene and Tropical Medicine. London, England
Federal University of Bahia. Center of Excellence in Asthma. Salvador, BA, Brazil
Johns Hopkins University. Division of Allergy and Clinical Immunology. Baltimore, Maryland
Johns Hopkins University. Division of Allergy and Clinical Immunology. Baltimore, Maryland
Johns Hopkins University. Division of Allergy and Clinical Immunology. Baltimore, Maryland
Johns Hopkins University. Division of Allergy and Clinical Immunology. Baltimore, Maryland
Johns Hopkins University. Division of Allergy and Clinical Immunology. Baltimore, Maryland
Johns Hopkins University. Division of Allergy and Clinical Immunology. Baltimore, Maryland
Johns Hopkins University. Division of Allergy and Clinical Immunology. Baltimore, Maryland / University of Colorado Denver. Department of Medicine. Aurora, Colorado
Abstract
Allergic asthma is a complex disorder that results from a combination of genetic and environmental factors. Studies suggest that helminth infections can activate a regulatory network characterized by the production of regulatory cytokines, such as interleukin 10 and transforming growth factor β1 (TGF-β1) and subsequently protect against immune-mediated diseases, such as asthma. On the other hand, TGF-β1 is increased in the lungs of individuals with asthma and may modulate airway inflammation. The role of TGF- β 1 single-nucleotide polymorphisms (SNPs) in allergic disease remains inconclusive. Objective: To evaluate the effects of genetic variations in the TGF-b1 on allergy and helminths infections in
children.
Methods: We tested for association among 4 TGF-b1 SNPs and allergic asthma, specific IgE, skin prick test
result, and IL-10 production in 1,335 Brazilians. In addition, we analyzed the association with markers of
helminth infection (parasite burden, anti-Ascaris IgE, and worm specific IgG4). The polymorphisms were
genotyped using Taq Man probes.
Results: We found an association between rs1800470 (C allele) and atopic wheezing (odds ratio [OR], 0.60;
95% confidence interval [CI], 0.37e0.95) and markers of allergy (OR, 0.41; 95% CI, 0.22e0.79). In contrast, a
positive association was observed between the haplotype ACCA and Trichuris trichiura infection (OR, 1.85;
P ¼ .003) and Ascaris lumbricoides infection (OR, 2.01; P < .001). This haplotype was also associated with
increased IL-10 production (b ¼ 50.7; P < .001).
Conclusion: Individuals with TGF-b1 polymorphisms have an increased susceptibility to helminth infections
and a lower risk of developing allergy. These studies suggest that immune modulation of allergic disease
results not only from environmental factors but also from genetic susceptibility and IL-10 production
Keywords in Portuguese
AsmaPolimorfismo
População
Helmintos
Infecções por Helmintos
Variação genética
Alergia
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