| Author | Azevedo, Kátia Martins Lopes de | |
| Author | Setúbal, Sérgio | |
| Author | Camacho, Luiz Antonio Bastos | |
| Author | Garcia, Rita de Cássia Nasser Cubel | |
| Author | Siqueira, Marilda Agudo Mendonça Teixeira de | |
| Author | Pereira, Renata Freire Alves | |
| Author | Oliveira, Solange Artimos de | |
| Access date | 2017-05-11T16:05:09Z | |
| Available date | 2017-05-11T16:05:09Z | |
| Document date | 2012 | |
| Citation | AZEVEDO, Kátia Martins Lopes de; Parvovirus B19 seroconversion in a cohort of human immunodeficiency virus-infected patients. Mem Inst Oswaldo Cruz, v.107, n.3, p.356-361, May 2012. | pt_BR |
| ISSN | 0074-0276 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/18824 | |
| Language | eng | pt_BR |
| Publisher | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Parvovirus B19 Humano | pt_BR |
| Subject in Portuguese | Anemia | pt_BR |
| Subject in Portuguese | Soroconversão | pt_BR |
| Subject in Portuguese | Infecção por HIV | pt_BR |
| Title | Parvovirus B19 seroconversion in a cohort of human immunodeficiency virus-infected patients | pt_BR |
| Type | Article | |
| Abstract | Erythrovirus B19 (B19V) infection may cause red cell aplasia in patients infected with human immunodeficiency virus (HIV). The introduction of highly active antiretroviral therapy (HAART) has improved the immune function of these patients by modifying the course of B19V infection. The purpose of this study was to estimate the frequency of B19 seroconversion in a cohort of HIV-infected patients and evaluate the occurrence of B19V-related anaemia during the seroconversion period. Adult HIV-infected patients were studied at a public hospital in Niterói, state of Rio de Janeiro, Brazil. IgG and IgM antibodies against B19V were detected by an enzyme-linked immunosorbent assay and B19 viraemia was assayed by polymerase chain reaction. Medical records were reviewed for any clinical evaluation of anaemia. Seroconversion was detected in 31.8% of the 88 individuals who began the study as anti-B19V IgG-negative. No clinical manifestations of B19V infection were detected during the period of seroconversion. Patients who seroconverted were 5.40 times more likely to have anaemia than those who did not [odds ratio 5.40 (95% confidence interval: 1.33-22.93)]. Anaemia was detected in eight patients. All patients recovered from anaemia by either beginning or continuing HAART, without requiring blood transfusions. In the HAART era, B19V infection may only be associated with a course of disease characterised by less severe chronic anaemia. This milder course of B19V-associated disease is likely due to the increased immune function of HAART-treated patients. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Instituto Biomédico. Disciplina de Doenças Infecciosas e Parasitárias. Niterói, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Instituto Biomédico. Disciplina de Doenças Infecciosas e Parasitárias. Niterói, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Departamento de Epidemiologia. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Instituto Biomédico. Departamento de Microbiologia e Parasitologia. Niterói, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Universidade do Grande Rio. Escola de Farmácia. Duque de Caxias, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Instituto Biomédico. Disciplina de Doenças Infecciosas e Parasitárias. Niterói, RJ, Brasil. | pt_BR |
| Subject | human parvovirus B19 | pt_BR |
| Subject | seroconversion | pt_BR |
| Subject | HIV infection | pt_BR |
| Subject | anaemia | pt_BR |
| e-ISSN | 1678-8060 | |
