| Author | Chvale, Helena | |
| Author | Oliveira, Joanna Reis Santos | |
| Author | Cruz, Alda Maria da | |
| Author | Enosse, Sonia | |
| Access date | 2017-05-16T12:19:41Z | |
| Available date | 2017-05-16T12:19:41Z | |
| Document date | 2012 | |
| Citation | CHAVALE, Helena; et al. Enhanced T cell activation in Plasmodium falciparum malaria-infected human immunodeficiency virus-1 patients from Mozambique. Mem Inst Oswaldo Cruz, v.107, n.8, p.985-992, Dec.2012. | pt_BR |
| ISSN | 0074-0276 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/18857 | |
| Language | eng | pt_BR |
| Publisher | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Malária | pt_BR |
| Subject in Portuguese | HIV | pt_BR |
| Subject in Portuguese | AIDS | pt_BR |
| Subject in Portuguese | Ativação celular | pt_BR |
| Subject in Portuguese | Plasmodium | pt_BR |
| Subject in Portuguese | Moçambique | pt_BR |
| Title | Enhanced T cell activation in Plasmodium falciparum malaria-infected human immunodeficiency virus-1 patients from Mozambique | pt_BR |
| Type | Article | |
| Abstract | Human immunodeficiency virus (HIV)-1 infection has an important impact on malaria. Plasmodium falciparum and HIV-1 co-infected patients (Pf/HIV) present with a high degree of anaemia, enhanced parasitaemia and decreased CD4+ T cell counts, which increase the risk of developing severe malaria. In addition, infection with either Pf or HIV-1 alone causes extensive immune activation. Our hypothesis was that lymphocyte activation is potentiated in Pf/HIV co-infected patients, consequently worsening their immunosuppressed state. To test this hypothesis, 22 Pf/HIV patients, 34 malaria patients, 29 HIV/AIDS patients and 10 healthy controls without malaria or HIV/acquired immune deficiency syndrome (AIDS) from Maputo/Mozambique were recruited for this study. As expected, anaemia was most prevalent in the Pf/HIV group. A significant variation in parasite density was observed in the Pf/HIV co-infected group (110-75,000 parasites/μL), although the median values were similar to those of the malaria only patients. The CD4+ T cell counts were significantly lower in the Pf/HIV group than in the HIV/AIDS only or malaria only patients. Lymphocyte activation was evaluated by the percentage of activation-associated molecules [CD38 expression on CD8+ and human leukocyte antigen-DR expression on CD3+ T cells]. The highest CD38 expression was detected in the Pf/HIV co-infected patients (median = 78.2%). The malaria only (median = 50%) and HIV/AIDS only (median = 52%) patients also exhibited elevated levels of these molecules, although the values were lower than those of the Pf/HIV co-infected cases. Our findings suggest that enhanced T-cell activation in co-infected patients can worsen the immune response to both diseases. | pt_BR |
| Affilliation | Ministério da Saúde. Instituto Nacional de Saúde. Maputo, Moçambique / Hospital Central de maputo. Laboratório de Biologia Molecular. Maputo, Moçambique. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Ministério da Saúde. Instituto Nacional de Saúde. Maputo, Moçambique / Hospital Central de maputo. Laboratório de Biologia Molecular. Maputo, Moçambique. | pt_BR |
| Subject | malaria/HIV-AIDS | pt_BR |
| Subject | cellular activation | pt_BR |
| Subject | Plasmodium | pt_BR |
| Subject | co-infection | pt_BR |
| Subject | CD4+ T cells | pt_BR |
| Subject | Mozambique | pt_BR |
| e-ISSN | 1678-8060 | |
