| Author | Halai, Umme-Aiman | |
| Author | Nielsen-Saines, Karin | |
| Author | Moreira, Maria Elisabeth Lopes | |
| Author | Sequeira, Patricia Carvalho de | |
| Author | Pereira Júnior, Jose Paulo | |
| Author | Zin, Andrea de Araujo | |
| Author | Cherry, James | |
| Author | Gabaglia, Claudia Raja | |
| Author | Gaw, Stephanie L. | |
| Author | Adachi, Kristina | |
| Author | Tsui, Irena | |
| Author | Pilotto, Jose Henrique | |
| Author | Nogueira, Rita Ribeiro | |
| Author | Filippis, Ana Maria Bispo de | |
| Author | Brasil, Patricia | |
| Access date | 2017-05-31T18:35:25Z | |
| Available date | 2017-05-31T18:35:25Z | |
| Document date | 2017 | |
| Citation | Halai, U. A. et al. Maternal Zika Virus disease severity, virus load, prior Dengue antibodies and their relationship to birth outcomes. Clinical Infectious Diseases, p. 1-30, May 2017. | |
| ISSN | 1537-6591 | |
| URI | https://www.arca.fiocruz.br/handle/icict/19076 | |
| Description | Versão Ahead of Print | pt_BR |
| Language | por | pt_BR |
| Publisher | Oxford | |
| Later version | https://www.arca.fiocruz.br/handle/icict/65784 | |
| Rights | open access | |
| Title | Maternal Zika Virus Disease Severity, Virus Load, Prior Dengue Antibodies and their Relationship to Birth Outcomes | en_US |
| Type | Preprint | |
| DOI | 10.1093/cid/cix472 | |
| Abstract | Background: Congenital Zika virus (ZIKV) syndrome is a newly identified condition resulting from infection during pregnancy. We analyzed outcome data from a mother-infant cohort in Rio de Janeiro in order to assess whether clinical severity of maternal ZIKV infection was associated with maternal virus load, prior dengue antibodies or abnormal pregnancy/infant outcomes. Methods: A clinical severity assessment tool was developed based on duration of fever, severity of rash, multisystem involvement and duration of symptoms during ZIKV infection. ZIKV-RNA load was quantified by PCR cycles in blood/ urine. Dengue IgG antibodies were measured at baseline. Adverse outcomes were defined as fetal loss or a live infant with grossly abnormal clinical or brain imaging findings. Regression models were used to study potential associations. Results: 131 ZIKV-PCR positive pregnant women were scored for clinical disease severity, 6 (4.6%) had mild disease, 98 (74.8%) had moderate disease and 27 (20.6%) severe manifestations of ZIKV infection. There were 58 (46.4%) abnormal outcomes with 9 fetal losses (7.2%) in 125 pregnancies. No associations were found between: disease severity and abnormal outcomes (p=0.961; OR:1.00; 95%CI: 0.796- 1.270); disease severity and viral load (p = 0.994); viral load and adverse outcomes (p=0.667; OR:1.02; 95%CI: 0.922- 1.135); or existence of prior dengue antibodies (88% subjects) with severity score, ZIKV-RNA load or adverse outcomes (p = 0.667; OR 0.78; 95%CI : 0.255 - 2.397). Conclusions: Congenital ZIKV syndrome does not appear to be associated with maternal disease severity, ZIKV-RNA load at time of infection or existence of prior dengue antibodies. | en_US |
| Affilliation | David Geffen UCLA School of Medicine. Los Angeles, CA, USA. | |
| Affilliation | David Geffen UCLA School of Medicine. Los Angeles, CA, USA. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de FlavivÍrus. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | David Geffen UCLA School of Medicine. Los Angeles, CA, USA. | |
| Affilliation | Biomedical Research Institute of Southern CA. Oceanside, CA, USA. | |
| Affilliation | University of CA San Francisco School of Medicine. San Francisco, CA, USA. | |
| Affilliation | David Geffen UCLA School of Medicine. Los Angeles, CA, USA. | |
| Affilliation | David Geffen UCLA School of Medicine. Los Angeles, CA, USA. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | David Geffen UCLA School of Medicine. Los Angeles, CA, USA. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | |
| Subject | Zika | en_US |
| Subject | Dengue | en_US |
| Subject | ZIKV | en_US |
| Subject | Pregnancy | en_US |
| Subject | Congenital | en_US |
| DeCS | Zika virus | pt_BR |
| DeCS | Dengue | pt_BR |
| Embargo date | 2018-05-23 | |
