Author | Teva, A. | |
Author | Porrozzi, R. | |
Author | Cupolillo, E. | |
Author | Pirmez, C. | |
Author | Oliveira Neto, M. P. | |
Author | Grimaldi Jr., Gabriel | |
Access date | 2017-06-06T17:00:46Z | |
Available date | 2017-06-06T17:00:46Z | |
Document date | 2003 | |
Citation | TEVA, A. et al. Leishmania (Viannia) braziliensis-induced chronic granulomatous cutaneous lesions affecting the nasal mucosa in the rhesus monkey (Macaca mulatta) model. Parasitology, v.127, p.437-447, 2003. | pt_BR |
ISSN | 0031-1820 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/19327 | |
Language | eng | pt_BR |
Publisher | Cambridge University Press | pt_BR |
Rights | restricted access | pt_BR |
Subject in Portuguese | Leishmania braziliensis | pt_BR |
Subject in Portuguese | Primatas | pt_BR |
Subject in Portuguese | Macaca mulatta | pt_BR |
Subject in Portuguese | Histopatologia | pt_BR |
Subject in Portuguese | Leishmaniose Mucocutânea | pt_BR |
Title | Leishmania (Viannia) braziliensis-induced chronic granulomatous cutaneous lesions affecting the nasal mucosa in the rhesus monkey (Macaca mulatta) model | pt_BR |
Type | Article | pt_BR |
DOI | 10.1017/S0031182003004037 | |
Abstract | The present studies on infections with Leishmania (Viannia) braziliensis in rhesus macaques were made to characterize the
evolution of different parasite strains and the immune responses they elicited in this experimental host. A standardized
inoculum of promastigotes was injected intradermally either above the eyelid or on the forearm of each monkey. Sixteen
infected monkeys developed longstanding infections which lasted until the end of the observation period (33 months). The
time required for lesion development was very variable, not only for the isolates showing molecular differences but also for
individual animals in groups infected with the same parasite strain. The inocula produced lesions of variable severity,
ranging from localized cutaneous leishmaniasis (CL) with a tendency to spontaneous healing to non-healing disease. One
infected animal developed persistent metastatic skin and mucosal lesions. Anti-Leishmania antibodies and parasite-specific
T-cell responses were induced by the experimental infections. As the granulomatous inflammatory response found at the
lesions in L. (V.) braziliensis-infected M. mulatta was similar to that in patients with CL, this primate model could be useful
for studying the pathophysiology and immunoregulatory events associated with disease evolution, as well as for the
evaluation of new drugs or candidate vaccines. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia. Rio de Janeiro, RJ. Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Biologia Celular e Ultraestrutural. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Biologia Molecular e Bioquímica. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Hospital e Centro de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia. Rio de Janeiro, RJ. Brasil. | pt_BR |
Subject | mucocutaneous leishmaniasis | pt_BR |
Subject | Leishmania (Viannia) braziliensis | pt_BR |
Subject | Primate | pt_BR |
Subject | Macaca mulatta | pt_BR |
Subject | histopathology | pt_BR |
e-ISSN | 1469-8161 | |
Embargo date | 2030-01-01 | |