| Author | Arruda, Valder Roberval | |
| Author | Grignolli, Carlos E | |
| Author | Gonçalves, Marilda de Souza | |
| Author | Soares, Manoel C | |
| Author | Menezes, Raimundo | |
| Author | Saad, Sara Teresinha Ollala | |
| Author | Costa, Fernando Ferreira | |
| Access date | 2017-06-07T16:07:29Z | |
| Available date | 2017-06-07T16:07:29Z | |
| Document date | 1998 | |
| Citation | ARRUDA, V. R. et al. Prevalence of homozygosity for the deleted alleles of glutathione S-transferase mu (GSTM1) and theta (GSTT1) among distinct ethnic groups from Brazil: relevance to environmental carcinogenesis? Clinical Genetics, v. 54, n. 3, p. 210-214, 1998. | pt_BR |
| ISSN | 0009-9163 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/19338 | |
| Description | Marilda de Souza Gonçalves “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. | pt_BR |
| Language | eng | pt_BR |
| Publisher | Wiley | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | DNA | pt_BR |
| Subject in Portuguese | Glutationa S transferase | pt_BR |
| Subject in Portuguese | PCR | pt_BR |
| Subject in Portuguese | Mutação | pt_BR |
| Title | Prevalence of homozygosity for the deleted alleles of glutathione S-transferase mu (GSTM1) and theta (GSTT1) among distinct ethnic groups from Brazil: relevance to environmental carcinogenesis? | pt_BR |
| Type | Article | pt_BR |
| Abstract | Environmental related diseases due to occupational carcinogens and
toxic substances are a serious problem particularly in developing countries.
The glutathione S-transferase system is fundamental for the
detoxification of numerous carcinogens and mutagens. The individual
inherited susceptibility to chemical carcinogenesis due to glutathione
S-transferase mu (GSTMl) and theta (GSTTl) varies significantly
among distinct ethnic groups. In this study we determined the prevalence
of the null genotype of the GSTMl and GSTTl genes among
individuals from three distinct Brazilian racial groups using a multiplex-
PCR methodology. The results showed that the highest prevalence
of the null genotype for the GSTMl occurred among Caucasians (55%,
allele frequency = 0.74), followed by 33% among Brazilian Black subjects
(allele frequency = 0.57). and 20% among Amazonian Indians (allele
frequency = 0.45). For GSTTl a homogenous distribution of the
null genotype was found among Caucasian and African descendants
(18.5 and 19% homozygotes, respectively, allele. frequency = 0.43). with
a lower prevalence among Amazonian Indians (1 1% of homozygotes,
a!lele frequency = 0.34). Whether the deficiency of the GST system contributes
to a predisposition to environmental related carcinogenesis in I specific popuiations in Brazil remains to be determined. | pt_BR |
| Affilliation | State Universtty of Campinas. Hematology-Hernotherapy Center. Campinas, SP, Brasil | pt_BR |
| Affilliation | State Universtty of Campinas. Hematology-Hernotherapy Center. Campinas, SP, Brasil | pt_BR |
| Affilliation | Federal University of Bahia. Saivador, BA, Brasil | pt_BR |
| Affilliation | Evandro Chagas Institute. Belélm, PA, Brasil | pt_BR |
| Affilliation | Evandro Chagas Institute. Belélm, PA, Brasil | pt_BR |
| Affilliation | State Universtty of Campinas. Hematology-Hernotherapy Center. Campinas, SP, Brasil | pt_BR |
| Affilliation | State Universtty of Campinas. Hematology-Hernotherapy Center. Campinas, SP, Brasil | pt_BR |
| Subject | DNA analysls | pt_BR |
| Subject | Glutathione S transferase mu | pt_BR |
| Subject | Glutathione S transferase mu theta gene | pt_BR |
| Subject | PCR | pt_BR |
| Subject | Mutation | pt_BR |
| DeCS | DNA | pt_BR |
| DeCS | Glutationa S transferase | pt_BR |
| DeCS | PCR | pt_BR |
| DeCS | Carcinogênese | pt_BR |
| DeCS | Mutação | pt_BR |
