Author | Cruz, Daniella Arêas Mendes da | |
Author | Stimamiglio, Marco Augusto | |
Author | Muñoz, Juan Jose | |
Author | Alfaro, David | |
Author | Terra-Granado, Eugênia | |
Author | Garcia-Ceca, Javier | |
Author | Alonso-Colmenar, Luis Miguel | |
Author | Savino, Wilson | |
Author | Zapata, Agustin G. | |
Access date | 2017-06-19T17:05:18Z | |
Available date | 2017-06-19T17:05:18Z | |
Document date | 2012 | |
Citation | CRUZ, Daniela Arêas Mendes da; et al. Developing T-cell migration: role of semaphorins and ephrins. The FASEB Journal, v.26, n.11 ,p:4390-4399, 2012. | pt_BR |
ISSN | 0892-6638 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/19406 | |
Language | eng | pt_BR |
Publisher | Federation of American Society of Experimental Biology | pt_BR |
Rights | restricted access | pt_BR |
Subject in Portuguese | Células epiteliais tímicas | pt_BR |
Subject in Portuguese | Timo | pt_BR |
Subject in Portuguese | Migração de timócitos | pt_BR |
Subject in Portuguese | Neuropilinas | pt_BR |
Title | Developing T-cell migration: role of semaphorins and ephrins | pt_BR |
Type | Article | pt_BR |
DOI | 10.1096/fj.11-202952 | |
Abstract | Cell migration is a crucial event for normal T-cell development, and various ligand/receptor pairs have been implicated. Most of them, including chemokines and extracellular matrix proteins, have attractant properties on thymocytes. We discuss herein two further groups of ligand/receptor pairs, semaphorins/neuropilins and ephs/ephrins, which are constitutively expressed by thymocytes and thymic microenvironmental cells. Evidence shows that the corresponding interactions are relevant for developing T-cell migration, including the entry of bone marrow progenitor cells, migration of CD4/CD8-defined thymocyte subpopulations triggered by chemokines and/or extracellular matrix proteins, and thymocyte export. Conceptually, the data summarized here show that thymocyte migration results from a complex network of molecular interactions, which generate not only attraction, but also repulsion of migrating T-cell precursors. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ. Brasil / Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Regulação da Expressão Genética. Curitiba. PR, Brasil / Complutense University. Faculty of Biology. Department of Cell Biology, Madrid, Spain. | pt_BR |
Affilliation | Complutense University. Faculty of Biology. Department of Cell Biology, Madrid, Spain. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ. Brasil / Complutense University. Department of Cell Biology, Faculty of Biology. Madrid, Spain / Instituto Nacional de CÂncer. Centro de Pesquisa. Programa de Oncologia e Hematologia Pediátrica. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Complutense University. Faculty of Biology. Department of Cell Biology, Madrid, Spain. | pt_BR |
Affilliation | Complutense University. Center of Cytometry and Fluorescence Microscopy. Madrid, Spain. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Complutense University. Faculty of Biology. Department of Cell Biology, Madrid, Spain / Complutense University. Center of Cytometry and Fluorescence Microscopy. Madrid, Spain.. | pt_BR |
Subject | thymus | pt_BR |
Subject | thymic epithelial cells | pt_BR |
Subject | thymocyte migration | pt_BR |
Subject | neuropilins | pt_BR |
Subject | ephs | pt_BR |
e-ISSN | 1530-6860 | |
Embargo date | 2030-01-01 | |