| Author | Borges, Juliana Pereira | |
| Author | França, Guilherme de Oliveira | |
| Author | Cruz, Mariana Delgado | |
| Author | Lanza, Rômulo | |
| Author | Nascimento, Alessandro Rodrigues do | |
| Author | Lessa, Marcos Adriano | |
| Access date | 2017-06-20T14:22:02Z | |
| Available date | 2017-06-20T14:22:02Z | |
| Document date | 2017 | |
| Citation | BORGES, Juliana Pereira; et al. Aerobic exercise training induces superior cardioprotection following myocardial ischemia reperfusion injury than a single aerobic exercise session in rats. Motriz, v.23, Special issue, e101620, 2017. | pt_BR |
| ISSN | 1980-6574 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/19434 | |
| Language | eng | pt_BR |
| Publisher | Universidade Estadual Paulista | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Isquemia e reperfusão | pt_BR |
| Subject in Portuguese | Treinamento de exercícios aeróbicos | pt_BR |
| Title | Aerobic exercise training induces superior cardioprotection following myocardial ischemia reperfusion injury than a single aerobic exercise session in rats | pt_BR |
| Type | Article | |
| DOI | 10.1590/S1980-6574201700SI0011 | |
| Abstract | Abstract — Aim: To compare the amount of cardioprotection induced by a single exercise session with those achieved
after an 8-week aerobic exercise training following ischemia reperfusion injury in rats. Methods: Twenty-five male
Wistar rats (250-300g) were assigned into a group submitted to physical training (TR; n=12) or a single maximal
exercise session (EXE; n=13). Following sedentarism or physical training (8 weeks, 5 sessions/wk, 1h/session at 70%
of maximal speed) both groups performed a maximal exercise test. Then, groups were submitted to ischemia reperfusion
injury (30 min/1h) through an isolated heart protocol, in which left ventricle developed pressure was measured.
Results: The TR group presented greater maximal oxygen consumption compared to the EXE group (77.25±20.41 vs
41.32±25.86 ml/Kg/min; P=0.003). Regarding left ventricle developed pressure, no differences were detected between
groups at baseline (TR: 89.78±24.40 vs EXE: 81.37±31.84 mmHg; P=0.48). However, after reperfusion, the TR group
presented superior intraventricular pressure than EXE group (37.94±18.34 vs 21.59±13.67 mmHg; P=0.03). Conclusion:
Eight-week aerobic training induced greater cardioprotection against ischemia reperfusion injury in rats compared to a
single exercise session, due to an increased cardiac function. This suggests that exercise-induced cardioprotection is a
multifactorial process that may involve different mediators according to the exercise duration. | pt_BR |
| Affilliation | Universidade do Estadol do Rio de Janeiro, Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade do Estadol do Rio de Janeiro, Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Subject | ischemia and reperfusion | pt_BR |
| Subject | aerobic exercise training | pt_BR |
| Subject | Langendorff | pt_BR |
