| Author | Cavalcanti, A. | |
| Author | Santos, R. | |
| Author | Mesquita, Z. | |
| Author | Duarte, A. L. B. P. | |
| Author | Lucena-Silva, N. | |
| Access date | 2017-06-21T17:58:17Z | |
| Available date | 2017-06-21T17:58:17Z | |
| Document date | 2017 | |
| Citation | CAVALCANTI, A. et al. Cytokine profile in childhood-onset systemic lupus erythematosus: a cross-sectional and longitudinal study. Brazilian Journal of Medical and Biological Research, v. 50, n. 4, 2017. | |
| ISSN | 1414-431X | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/19475 | |
| Language | eng | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Citocinas | |
| Subject in Portuguese | Lúpus eritematoso sistêmico de início na infância | |
| Subject in Portuguese | Atividade de doença | |
| Subject in Portuguese | SLEDAI-2K | |
| Subject in Portuguese | Inflamação | |
| Title | Cytokine profile in childhood-onset systemic lupus erythematosus: a cross-sectional and longitudinal study | pt_BR |
| Type | Article | en |
| DOI | 10.1590/1414-431X20175738 | pt_BR |
| Abstract | Childhood-onset systemic lupus erythematosus (cSLE) exhibits an aggressive clinical phenotype and severe complications. This could be due to a pro-inflammatory cytokine milieu. Therefore, we determined plasma levels of Th1 (IL-2, IFN-γ, TNF), Th2 (IL-4), Th17 (IL-17A, IL-6), and Treg (IL-10) cytokines in a cohort of cSLE patients and healthy controls, and we evaluated the association between these cytokines and disease activity. We conducted a cross-sectional study with 51 cSLE patients from two pediatric rheumatology services. Ten cSLE patients participated in a longitudinal follow-up study. Blood samples were collected from the same patient during active and inactive disease. Disease activity was evaluated according to SLE Disease Activity Index 2000 (SLEDAI-2K). Cytokines levels were measured by cytometric bead array technique. cSLE patients had higher IL-6 (P<0.001) and IL-10 (P<0.001) levels than healthy controls. Patients with active disease had higher IL-6 and IL-10 levels than patients with inactive disease (P=0.001 and P=0.014, respectively) and the control group (both P<0.001). IL-6 (P=0.022), IL-10 (P=0.013), and IL-17A (P=0.041) levels were significantly higher during active than inactive disease. Linear regression analysis revealed IL-6 (P=0.002, 95%CI=0.006-0.025) and IL-10 (P=0.01 95%CI=0.021-0.150) as independent factors for increased SLEDAI-2K. IL-6, IL-10, and IL-17A are candidate biomarkers for disease activity in cSLE patients. This is the first longitudinal study to support their pivotal role in the pathogenesis of the disease. | |
| Affilliation | Universidade Federal de Pernambuco. Hospital das Clínicas. Unidade de Reumatologia. Recife, PE, Brasil / Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Imunologia. Recife, PE, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Imunologia. Recife, PE, Brasil. | |
| Affilliation | Instituto de Medicina Integral Professor Fernando Figueira. Unidade de Reumatologia Pediátrica. Recife, PE, Brasil. | |
| Affilliation | Universidade Federal de Pernambuco. Hospital das Clínicas. Unidade de Reumatologia. Recife, PE, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Imunologia. Recife, PE, Brasil / Instituto de Medicina Integral Professor Fernando Figueira. Unidade de Oncologia Pediátrica. Recife, PE, Brasil. | |
| Subject | Cytokines | |
| Subject | Childhood-onset systemic lupus erythematosus | |
| Subject | Disease activity | |
| Subject | SLEDAI-2K | |
| Subject | Inflammation | |
| DeCS | Lúpus Eritematoso Sistémico , Sistémico / sangue | |
| DeCS | Citocinas / sangue | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
