| Author | Spitz, Natália | |
| Author | Moreira, Aline S. | |
| Author | Mello, Francisco C. A. | |
| Author | Franz, Helena Cristina F. | |
| Author | Gomes, Selma A. | |
| Author | Araujo, Natalia M. | |
| Access date | 2017-07-05T16:44:08Z | |
| Available date | 2017-07-05T16:44:08Z | |
| Document date | 2017 | |
| Citation | SPITZ, Natalia; et al. Complete genome sequence of a hepatitis B virus isolate of genotype D2, subtype adrq+, from Brazil. Arch Virol, v.162, p.1695-1700, 2017. | pt_BR |
| ISSN | 0304-8608 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/19730 | |
| Language | eng | pt_BR |
| Publisher | Springer Verlag (Germany) | pt_BR |
| Rights | restricted access | pt_BR |
| Subject in Portuguese | Vírus da Hepatite B | pt_BR |
| Subject in Portuguese | Sequência genômica | pt_BR |
| Subject in Portuguese | Genótipo | pt_BR |
| Title | Complete genome sequence of a hepatitis B virus isolate of genotype D2, subtype adrq+, from Brazil | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1007/s00705-017-3269-5 | |
| Abstract | Hepatitis B virus (HBV) has been classified into 10 distinct serological subtypes of the surface antigen (HBsAg) that can be predicted by sequencing of the corresponding S gene. HBV genotype D usually displays determinants of subtypes ayw2 or ayw3. On the other hand, subtype adrq+ has been found exclusively in association with genotype C. Here, we describe the first HBV genome (isolate BR32) belonging to genotype D with the serological subtype adrq+. This isolate had a genome length of 3,062 nucleotides (nt), and no recombination events were observed in the BR32 genome that could explain the occurrence of the subtype adr in a genotype D isolate. Analysis of the quasispecies population revealed that 28 out of 30 clones (93%) were of subtype adrq+, while the subtypes of the two remaining could not be determined, since they contained an S residue (instead of K or R) at position 122 of HBsAg. These results will contribute to further epidemiological and evolutionary studies of HBV. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Universidade Federal de Santa Catarina. Departamento de Análises Clínicas. Florianópolis, SC, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Subject | Hepatitis B virus | pt_BR |
| Subject | genome sequence | pt_BR |
| Subject | genotype D2 | pt_BR |
| Subject | subtype adrq+ | pt_BR |
| Subject | Brazil | pt_BR |
| e-ISSN | 1432-8798 | |
| Embargo date | 2030-01-01 | |
