| Author | Pereira, Luiza de Oliveira Ramos | |
| Author | Moreira, Regina Barbosa | |
| Author | Oliveira, Márcia Pereira de | |
| Author | Reis, Soraya de Oliveira | |
| Author | Oliveira Neto, Manoel Paes de | |
| Author | Pirmez, Claude | |
| Access date | 2017-07-11T16:57:49Z | |
| Available date | 2017-07-11T16:57:49Z | |
| Document date | 2017 | |
| Citation | PEREIRA, Luiza de Oliveira Ramos et al. Is Leishmania (Viannia) braziliensis parasite load associated with disease pathogenesis? International Journal of Infectious Diseases, v. 57, p. 132–137, 2017. | pt_BR |
| ISSN | 1201-9712 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/20043 | |
| Description | This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | pt_BR |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Leishmania braziliensis | pt_BR |
| Subject in Portuguese | Carga parasitária | pt_BR |
| Subject in Portuguese | Falha terapêutica | pt_BR |
| Title | Is Leishmania (Viannia) braziliensis parasite load associated with disease pathogenesis? | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.ijid.2017.01.036 | |
| Abstract | Leishmania (Viannia) braziliensis is the main etiological agent of tegumentary leishmaniasis in the Americas. Parasite molecular diversity and host immune status contribute to extensive variations in its clinical presentation within endemic areas of Brazil. Pentavalent antimonials have been used for more than 60 years as the first-line drug for all cases, despite the potential for severe side effects and refractoriness. In Rio de Janeiro, Brazil, most L. (V.) braziliensis infections are benign with a scarcity of parasites, although metastasis and refractory infections can arise. In this scenario, the use of novel molecular tools can be useful for diagnosis and to assess tissue parasitism, and is of benefit to clinical and therapeutic management. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmaniose. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Subject | Parasitic load | pt_BR |
| Subject | Therapeutic failure | pt_BR |
| Subject | Leishmania (Viannia) braziliensis | pt_BR |
| Subject | Small subunit ribosomal RNA gene | pt_BR |
| e-ISSN | 1878-3511 | |
