| Author | Almeida, Roque Pacheco de | |
| Author | D'Oliveira Júnior, Argemiro | |
| Author | Machado, Paulo Roberto Lima | |
| Author | Bacellar, Maria Olívia Amado Ramos | |
| Author | Ko, Albert Icksang | |
| Author | Jesus, Amélia Maria Ribeiro de | |
| Author | Mobashery, N | |
| Author | Santos, Jussamara Brito | |
| Author | Carvalho Filho, Edgar Marcelino | |
| Access date | 2017-07-13T13:38:18Z | |
| Available date | 2017-07-13T13:38:18Z | |
| Document date | 1999 | |
| Citation | ALMEIDA, R. P. et al. Randomized, double-blind study of stibogluconate plus human granulocyte macrophage colony-stimulating factor versus stibogluconate alone in the treatment of cutaneous Leishmaniasis. Journal of Infectious Diseases, v. 180, p. 1735–1737, 1999. | pt_BR |
| ISSN | 0022-1899 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/20072 | |
| Description | Ko, Albert Icksang “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. | pt_BR |
| Sponsorship | National Institutes of Health grant AI-30639 and by Financiadora de Estudos e Projetos, Centro de Apoio ao Desenvolvimento da Ciência e Tecnologia, and Programa de Apoio aos Núcleos de Excelência. | pt_BR |
| Language | eng | pt_BR |
| Publisher | Oxford University Press | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Leishmaniose cutânea | pt_BR |
| Subject in Portuguese | Gluconato de antimônio e sódio | pt_BR |
| Subject in Portuguese | Agentes antiprotozoários | pt_BR |
| Subject in Portuguese | Fator Estimulador de Colônia de Granulócitos | pt_BR |
| Subject in Portuguese | Criança | pt_BR |
| Subject in Portuguese | Humanos | pt_BR |
| Title | Randomized, double-blind study of stibogluconate plus human granulocyte macrophage colony-stimulating factor versus stibogluconate alone in the treatment of cutaneous Leishmaniasis | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1086/315082 | |
| Abstract | The response to recombinant human granulocyte macrophage colony-stimulating factor (GM-CSF) in the treatment of cutaneous leishmaniasis was evaluated. Twenty patients with cutaneous leishmaniasis who had lesions for 60 days were enrolled in a double-blind placebo trial of GM-CSF with standard parenteral sodium stibogluconate (20 mg/kg-1/day-1) for 20 days. Ten patients were randomized to receive intralesionally injected GM-CSF (200 microgram) at enrollment and 1 week after, and 10 patients received saline as placebo. GM-CSF- and antimony-treated patients healed faster than patients who received antimony alone (49+/-32.8 vs. 110+/-61.6 days, P<.05). Seven of 10 patients were healed of their lesions before 40 days after therapy in the GM-CSF group, compared with only 1 of 10 patients in the placebo group (relative risk, 7; 95% confidence interval, 1.04-47.00). Thus, GM-CSF plus antimony significantly increased the chance of lesion healing in 40 days. | pt_BR |
| Affilliation | Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil | pt_BR |
| Affilliation | Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil | pt_BR |
| Affilliation | Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil | pt_BR |
| Affilliation | Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil | pt_BR |
| Affilliation | Cornell University Medical College. NY Hospital. Division of International Health and Infectious Diseases. Department of Medicine. New York, NY | pt_BR |
| Affilliation | Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil | pt_BR |
| Affilliation | Cornell University Medical College. NY Hospital. Division of International Health and Infectious Diseases. Department of Medicine. New York, NY | pt_BR |
| Affilliation | Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil | pt_BR |
| Affilliation | Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil | pt_BR |
| Subject | Leishmaniasis, Cutaneous | pt_BR |
| Subject | Antimony Sodium Gluconate | pt_BR |
| Subject | Antiprotozoal Agents | pt_BR |
| Subject | Granulocyte-Macrophage Colony-Stimulating Factor | pt_BR |
| Subject | Child | pt_BR |
| Subject | Humans | pt_BR |
