| Author | Siqueira, Liliane Maria Vidal | |
| Author | Couto, Flavia Fernanda Bubula | |
| Author | Taboada, Diana Cordeiro | |
| Author | Oliveira, Áureo Almeida de | |
| Author | Carneiro, Nidia Francisca de Figueiredo | |
| Author | Oliveira, Edward Jose de | |
| Author | Coelho, Paulo Marcos Zech | |
| Author | Katz, Naftale | |
| Access date | 2017-07-13T17:44:28Z | |
| Available date | 2017-07-13T17:44:28Z | |
| Document date | 2016 | |
| Citation | SIQUEIRA, Liliane Maria Vidal et al. Performance of POC-CCA® in diagnosis of schistosomiasis mansoni in individuals with low parasite burden. Rev. Soc. Bras. Med. Trop., v. 49, n. 3, p. 341-347, 2016 | pt_BR |
| ISSN | 0037-8682 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/20083 | |
| Language | eng | pt_BR |
| Publisher | Sociedade Brasileira de Medicina Tropical | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Schistosoma mansoni | pt_BR |
| Subject in Portuguese | Esquistossomose | pt_BR |
| Title | Performance of POC-CCA® in diagnosis of schistosomiasis mansoni in individuals with low parasite burden | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1590/0037-8682-0070-2016 | |
| xmlui.metadata.dc.description.abstractes | INTRODUCTION: Schistosomiasis, caused by Schistosoma mansoni, is a public health concern in Brazil. However, the most popular diagnostic method, the Kato-Katz technique, exhibits low sensitivity in low-endemicity areas. We aimed to compare the performance of an immunological assay, the point-of-care circulating cathodic antigen (POC-CCA®) test, with that of two parasitological techniques in a low-endemicity population.
METHODS: Our study included 141 individuals living in Estreito de Miralta, Minas Gerais, Brazil. Fecal samples were obtained from all participants and analyzed for schistosomiasis using two parasitological techniques: the Kato-Katz technique and the saline gradient technique. Additionally, POC-CCA® strips were utilized for testing urine samples. The results obtained by the different techniques were compared.
RESULTS: Analysis of two or 24 slides using the Kato-Katz technique resulted in a positivity rate of 10.6% (15/141) or 19.1% (27/141), respectively. The saline gradient technique yielded a positivity rate of 17.0% (24/141). The prevalence according to both parasitological techniques was 24.1% (34/141). The POC-CCA® test yielded a positivity rate of 22.7% (32/141); however, the positivity rate was merely 2.1% if trace results were considered negative. The agreements observed between POC-CCA® and the parasitological techniques were good (Kappa indexes > 0.64). The POC-CCA® test was more sensitive than the two-slide Kato-Katz technique (p < 0.05) in detecting cases of S. mansoni infection when trace results were considered positive.
CONCLUSIONS: These findings reinforce the importance of using multiple diagnostic techniques in low-endemicity areas for effective control of disease. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Esquistossomose. Belo Horizonte, MG, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Esquistossomose. Belo Horizonte, MG, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Esquistossomose. Belo Horizonte, MG, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Esquistossomose. Belo Horizonte, MG, Brasil | pt_BR |
| Affilliation | Centro de Controle de Zoonoses de Montes Claros. Montes Claros. MG, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Pesquisas Clínicas. Belo Horizonte, MG, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Esquistossomose. Belo Horizonte, MG, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Esquistossomose. Belo Horizonte, MG, Brasil | pt_BR |
| Subject | Schistosoma mansoni | pt_BR |
| Subject | Schistosomiasis | pt_BR |
| Subject | Diagnosis | pt_BR |
| Subject | Low parasite burden | pt_BR |
