| Author | Nabuco, Letícia Cancella | |
| Author | Mello, Francisco Campello do Amaral | |
| Author | Gomes, Selma de Andrade | |
| Author | Perez, Renata Mello | |
| Author | Coelho, Henrique Sérgio Moraes | |
| Author | Nogueira, Cristiane Alves Villela | |
| Access date | 2017-07-20T15:16:26Z | |
| Available date | 2017-07-20T15:16:26Z | |
| Document date | 2012 | |
| Citation | NABUCO, Letícia Cancella; et al. Hepatitis B virus genotypes in Southeast Brazil and its relationship with histological features. Mem Inst Oswaldo Cruz, v.107, n.6, p.758-789, Sept. 2012. | pt_BR |
| ISSN | 0074-0276 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/20157 | |
| Language | eng | pt_BR |
| Publisher | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Hepatite B | pt_BR |
| Subject in Portuguese | Vírus da Hepatite B | pt_BR |
| Subject in Portuguese | Genótipo | pt_BR |
| Subject in Portuguese | Histologia do fígado | pt_BR |
| Subject in Portuguese | Sudeste do Brasil | pt_BR |
| Title | Hepatitis B virus genotypes in Southeast Brazil and its relationship with histological features | pt_BR |
| Type | Article | |
| Abstract | Data concerning the relationship between hepatitis B virus (HBV) genotypes and liver histology are scarce.
The aim of this study was to compare HBV non-B and non-C genotypes according to demographic features, clinical
status, HBV-DNA levels and liver histology in Rio de Janeiro. One hundred twenty one consecutive chronic HBVinfected
patients were enrolled during two-year period and data were prospectively collected. Sera were tested for
HBV genotyping using restriction fragment length polymorphism. Liver biopsy was obtained from patients with
either increased alanine aminotransferase (ALT) or HBV-DNA levels. Genotype A was the most common, found in
82 (68%) patients, followed by F in 19 (15%), D in 17 (14%), B in one (1%) and C in two (2%). There was no association
between HBV genotypes A, D and F and gender (p = 0.37), age (p = 0.78), race (p = 0.22), mode of infection (p
= 0.94), HB “e” antigen status (p = 0.37) and HBV-DNA levels (p = 0.47). The ALT levels were lower in genotype D
(75%) compared with A (47%) and F (55%) (p = 0.05). Liver biopsy showed lower inflammation [histological activity
index (HAI) = 4] and fibrosis (F) (= 0) scores in genotype D than in genotypes A (HAI = 5, p < 0.001; F = 2, p
= 0.008) or F (HAI = 5, p = 0.009; F = 2, p = 0.01). Genotype A was the most prevalent in chronic HBV-infected
patients and genotype D patients presented with less intense liver disease. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Divisão de Histopatologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Divisão de Histopatologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Divisão de Histopatologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Divisão de Histopatologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Divisão de Histopatologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | HBV genotypes | pt_BR |
| Subject | hepatitis B | pt_BR |
| Subject | HBV-DNA | pt_BR |
| Subject | liver histology | pt_BR |
| Subject | HBeAg | pt_BR |
| Subject | ALT | pt_BR |
| Subject | Southeast Brazil | pt_BR |
| e-ISSN | 1678-8060 | |
