| Author | Andrade, Bruno de Bezerril | |
| Author | Pavan Kumar, Nathella | |
| Author | Amaral, Eduardo Pinheiro | |
| Author | Riteau, Nicolas | |
| Author | Mayer-Barber, Katrin D | |
| Author | Tosh, Kevin W | |
| Author | Maier, Nolan | |
| Author | Conceição, Elisabete Lopes | |
| Author | Kubler, Andre | |
| Author | Sridhar, Rathinam | |
| Author | Banurekha, Vaithilingam V | |
| Author | Jawahar, Mohideen S | |
| Author | Bessa, Theolis Costa Barbosa | |
| Author | Manganiello, Vincent C | |
| Author | Moss, Joel | |
| Author | Fontana, Joseph R | |
| Author | Marciano, Beatriz E | |
| Author | Sampaio, Elizabeth P | |
| Author | Olivier, Kenneth N | |
| Author | Holland, Steven M | |
| Author | Jackson, Sharon H | |
| Author | Moayeri, Mahtab | |
| Author | Leppla, Stephen | |
| Author | Sereti, Irini | |
| Author | Barber, Daniel L | |
| Author | Nutman, Thomas B | |
| Author | Babu, Subash | |
| Author | Sher, Alan | |
| Access date | 2017-07-21T17:57:14Z | |
| Available date | 2017-07-21T17:57:14Z | |
| Document date | 2015 | |
| Citation | ANDRADE, B. B. et al. Heme Oxygenase-1 Regulation of Matrix Metalloproteinase-1 Expression Underlies Distinct Disease Profiles in Tuberculosis. The Journal of Immunology, v. 195, n. 6, p. 2763–2773, 2015. | pt_BR |
| ISSN | 0022-1767 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/20169 | |
| Description | Andrade, Bruno de Bezerril; Bessa, Theolis Costa Barbosa. Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Unidade de Medicina Investigativa. Laboratório Integrado de Microbiologia e Imunorregulação. Salvador, BA, Brasil *Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; †Unidade de Medicina Investigativa, Laborato´rio Integrado de Microbiologia e Imunorregulação, Centro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador 40296-710, Brazil; ‡National Institutes of Health, International Center for Excellence in Research, Chennai 600031, India; xNational Institute for Research in Tuberculosis, Chennai 600031, India; {Microbial Pathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; ‖Department of Medicine, Imperial College London, London SW7 2AZ, United Kingdom; #Government Stanley Medical Hospital, Chennai 600001, India; **Cardiovascular and Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892; ††Immunopathogenesis Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; ‡‡Division of Intramural Research, National Institute on Minority Health and Health Disparities, National Institutes of Health, Bethesda, MD 20892; xxClinical and Molecular Retrovirology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; {{T-Lymphocyte Biology Unit, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health,
Bethesda, MD 20892; ‖‖Helminth Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 | pt_BR |
| Sponsorship | Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health. J.M., V.C.M., and J.R.F. were supported by the National Heart, Lung, and Blood Institute Intramural Research Program. The Brazilian study was funded by Fundação de Amparo à Pesquisa do Estado da Bahia and Conselho Nacional de Desenvolvimento Cientı´fico e Tecnológico, Brazil (Grant 028/2010). | pt_BR |
| Language | eng | pt_BR |
| Publisher | American Association of Immunologists | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Tuberculose, Pulmonar | pt_BR |
| Subject in Portuguese | Matrix Metalloproteinase 1 | pt_BR |
| Subject in Portuguese | Heme Oxygenase-1 | pt_BR |
| Subject in Portuguese | Mycobacterium tuberculosis | pt_BR |
| Subject in Portuguese | Macrófagos | pt_BR |
| Subject in Portuguese | Biomarcadores | pt_BR |
| Subject in Portuguese | Humanos | pt_BR |
| Subject in Portuguese | Adulto | pt_BR |
| Title | Heme Oxygenase-1 Regulation of Matrix Metalloproteinase-1 Expression Underlies Distinct Disease Profiles in Tuberculosis | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.4049/jimmunol.1500942 | |
| Abstract | Pulmonary tuberculosis (TB) is characterized by oxidative stress and lung tissue destruction by matrix metalloproteinases (MMPs). The interplay between these distinct pathological processes and the implications for TB diagnosis and disease staging are poorly understood. Heme oxygenase-1 (HO-1) levels were previously shown to distinguish active from latent TB, as well as successfully treated Mycobacterium tuberculosis infection. MMP-1 expression is also associated with active TB. In this study, we measured plasma levels of these two important biomarkers in distinct TB cohorts from India and Brazil. Patients with active TB expressed either very high levels of HO-1 and low levels of MMP-1 or the converse. Moreover, TB patients with either high HO-1 or MMP-1 levels displayed distinct clinical presentations, as well as plasma inflammatory marker profiles. In contrast, in an exploratory North American study, inversely correlated expression of HO-1 and MMP-1 was not observed in patients with other nontuberculous lung diseases. To assess possible regulatory interactions in the biosynthesis of these two enzymes at the cellular level, we studied the expression of HO-1 and MMP-1 in M. tuberculosis-infected human and murine macrophages. We found that infection of macrophages with live virulent M. tuberculosis is required for robust induction of high levels of HO-1 but not MMP-1. In addition, we observed that CO, a product of M. tuberculosis-induced HO-1 activity, inhibits MMP-1 expression by suppressing c-Jun/AP-1 activation. These findings reveal a mechanistic link between oxidative stress and tissue remodeling that may find applicability in the clinical staging of TB patients. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Unidade de Medicina Investigativa. Laboratório Integrado de Microbiologia e Imunorregulação. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Unidade de Medicina Investigativa. Laboratório Integrado de Microbiologia e Imunorregulação. Salvador, BA, Brasil | pt_BR |
| Affilliation | Múltipla – ver em Notas | pt_BR |
| Subject | Tuberculosis, Pulmonary | pt_BR |
| Subject | Matrix Metalloproteinase 1 | pt_BR |
| Subject | Heme Oxygenase-1 | pt_BR |
| Subject | Mycobacterium tuberculosis | pt_BR |
| Subject | Macrophages | pt_BR |
| Subject | Biomarkers | pt_BR |
| Subject | Humans | pt_BR |
| Subject | Adult | pt_BR |
| Subject | Oxidative Stress | pt_BR |
| Subject | Estresse oxidativo | pt_BR |
