Author | Sleigh, Adrian C | |
Author | Mott, Kenneth E | |
Author | Silva, J. T. França | |
Author | Muniz, Tácito M | |
Author | Mota, Eduardo Luiz Andrade | |
Author | Barreto, Maurício Lima | |
Author | Hoff, Rodney | |
Author | Maguire, James H | |
Author | Lehman, J. S | |
Author | Sherlock, Ítalo Rodrigues de Araújo | |
Access date | 2017-07-24T17:32:10Z | |
Available date | 2017-07-24T17:32:10Z | |
Document date | 1981 | |
Citation | SLEIGH, A. C. et al. A three year follow-up of chemotherapy with oxamniquine in a Brazilian community with endemic schistosomiasis mansoni. Transactions of The Royal Society of Tropical Medicine and Hygiene, v. 75, n. 2, p. 234-238, 1981. | pt_BR |
ISSN | 0035-9203 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/20379 | |
Sponsorship | Organização Pan-Americana da Saúde e Indústria e Comercio S.A. (ICOMI). | pt_BR |
Language | eng | pt_BR |
Publisher | Oxford University Press | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Esquistossomose mansoni | pt_BR |
Subject in Portuguese | Quimioterapia | pt_BR |
Subject in Portuguese | Oxamniquine | pt_BR |
Subject in Portuguese | Prevalência | pt_BR |
Subject in Portuguese | Humanos | pt_BR |
Subject in Portuguese | Tratamento | pt_BR |
Title | A three year follow-up of chemotherapy with oxamniquine in a Brazilian community with endemic schistosomiasis mansoni | pt_BR |
Type | Article | pt_BR |
Abstract | Oral oxamniquine was tested as a control strategy
for endemic schistosomiasis in a rural area of
Bahia, Brazil. Adults were treated with a single
dose (12 * 5 to 15 mg per kg) and children ( < 12
years old) with a total of 20 mg per kg in two doses.
The 191 (infected) persons treated represented
69% of the infected population in the study area.
Follow-up stool examinations (Kato-Katz method)
at one, 3, 6,13,25 and 33 months showed the cure
rate declining from 80% at three months to 46%
at 33 months. Over one half of those not cured
showed a decrease in egg counts throughout the
follow-up which, after 33 months, remained
66% below the pre-treatment levels. Stool examinations
conducted on all study area residents
during three years before chemotherapy showed
the prevalence and intensity of Schistosoma mansoni
infection to be high and stable. 33 months after
the chemotherapy the prevalence was 41% and for
infected individuals the geometric mean egg count
was 121 epg, a decline of respectively 35y0 and
4074 from pre-treatment levels for each index.
Chemotherapy of infected persons with oxamniquine
protected the community as a whole from high
worm burdens for almost three years, although at
this point the prevalence began to rise towards
pretreatment levels. | pt_BR |
Affilliation | Harvard School of Public Health. Department of Tropical Public Health. Boston, MA, USA | pt_BR |
Affilliation | Harvard School of Public Health. Department of Tropical Public Health. Boston, MA, USA | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Federal University of Bahia. Salvador, BA, Brazil | pt_BR |
Affilliation | Universidade Federal da Bahia. Departamento de Medicina Preventiva. Salvador, BA, Brasil | pt_BR |
Affilliation | Harvard School of Public Health. Department of Tropical Public Health. Boston, MA, USA | pt_BR |
Affilliation | Harvard School of Public Health. Department of Tropical Public Health. Boston, MA, USA | pt_BR |
Affilliation | Sem afiliação | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Subject | Schistosomiasis mansoni | pt_BR |
Subject | Chemotherapy | pt_BR |
Subject | Oxamniquine | pt_BR |
Subject | Prevalence | pt_BR |
Subject | Humans | pt_BR |
Subject | Treatment | pt_BR |