| Author | Oliveira, Geraldo Gileno de Sá | |
| Author | Hutchings, P. R | |
| Author | Roitt, I. M | |
| Author | Lydyard, P. M | |
| Access date | 2017-07-26T18:11:52Z | |
| Available date | 2017-07-26T18:11:52Z | |
| Document date | 1994 | |
| Citation | OLIVEIRA, G. G. S. et al. Production of erythrocyte autoantibodies in NZB mice is inhibited by CD4 antibodies. Clinical Experimental Immunology, v. 96, n. 2, p. 297-302, 1994. | pt_BR |
| ISSN | 0009-9104 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/20417 | |
| Description | Oliveira, Geraldo Gileno de Sá “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. | pt_BR |
| Sponsorship | Brazilian Council for Development of Research and Technology (CNPq). | pt_BR |
| Language | eng | pt_BR |
| Publisher | Wiley | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Ratos | pt_BR |
| Subject in Portuguese | Doenças autoimunes | pt_BR |
| Subject in Portuguese | Anticorpos | pt_BR |
| Subject in Portuguese | Antígeno CD4 | pt_BR |
| Title | Production of erythrocyte autoantibodies in NZB mice is inhibited by CD4 antibodies | pt_BR |
| Type | Article | pt_BR |
| Abstract | NZB mice spontaneously develop haemolytic anaemia as the result of production of erythrocyte
autoantibodies. The mechanisms leading to breakdown in tolerance to erythrocyte autoantigens
are unknown. Antibodies to CD4 have been successfully used to treat several murine models of
autoimmune disease. In this study we injected NZB mice with non-depleting CD4 antibodies and
were able to prevent and abrogate erythrocyte autoantibody production in young (Coombs'
negative) and old (Coombs' positive) mice, respectively. Our data indicate the dependency of
autoantibody production on CD4+ T cells. However, withdrawal of anti-CD4 antibodies resulted
in the appearance of erythrocyte autoantibodies, showing that under these conditions we were
unable to re-establish tolerance to autoantigens on erythrocytes using anti-CD4 treatment. | pt_BR |
| Affilliation | University College London Medical School. London, UK | pt_BR |
| Affilliation | University College London Medical School. London, UK | pt_BR |
| Affilliation | University College London Medical School. London, UK | pt_BR |
| Affilliation | University College London Medical School. London, UK | pt_BR |
| Subject | NZB mice | pt_BR |
| Subject | Therapy of autoimmune disease | pt_BR |
| Subject | Anti-CD4 antibodies | pt_BR |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
