| Author | Cotrim, Helma Pinchemel | |
| Author | Freitas, Luiz Antonio Rodrigues de | |
| Author | Freitas, Carolina | |
| Author | Braga, Luciana | |
| Author | Sousa, Rodrigo | |
| Author | Carvalho, Fernando Martins | |
| Author | Paraná, Raymundo | |
| Author | Jesus, Rogerio Santos de | |
| Author | Andrade, Zilton de Araújo | |
| Access date | 2017-07-27T18:26:31Z | |
| Available date | 2017-07-27T18:26:31Z | |
| Document date | 2004 | |
| Citation | COTRIM, H. P. et al. Clinical and histopathological features of NASH in workers exposed to chemicals with or without associated metabolic conditions. Liver International, v. 24, n. 2, p. 131–135, 2004. | pt_BR |
| ISSN | 1478-3223 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/20434 | |
| Description | Freitas, Luiz Antonio Rodrigues de; Andrade, Zilton de Araújo “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. | pt_BR |
| Language | eng | pt_BR |
| Publisher | Wiley | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Hepatotoxicidade industrial | pt_BR |
| Subject in Portuguese | Esteato-hepatite não alcoólica | pt_BR |
| Subject in Portuguese | Exposição ocupacional | pt_BR |
| Title | Clinical and histopathological features of NASH in workers exposed to chemicals with or without associated metabolic conditions | pt_BR |
| Type | Article | pt_BR |
| Abstract | Non-alcoholic steatohepatitis (NASH) has been associated with exposure to chemicals among workers from an industrial complex in Brazil. We investigated the NASH profile of these individuals associated or not with metabolic conditions. Methods: Eighty-four patients
with NASH were classified into three groups: G1, 31 patients exposed to
chemicals (benzene, xylene, vinyl chloride and others); G2, 30 exposed
patients who also presented with obesity, hyperlipidemia and diabetes; and
G3, 23 non-exposed patients who presented with metabolic conditions.
Results: G1 and G2 were similar in terms of gender (97% and 100% males)
and age (37 5.4 and 39 6.5 years). In G3, 74% were males and the age
was 48 3.4 years (Po0.05). In G2, obesity was present in 26.6%,
hyperlipidemia in 66.6% and diabetes in 6.6%. In G3, obesity was observed
in 43.4%, hyperlipidemia in 30.4% and diabetes in 26%. Macro- and
microsteatosis were observed in 100% of cases. Perisinusoidal fibrosis was
observed in 71% patients in G1, 80% in G2 and 52% in G3 (Po0.05).
Histological evidence of cholestasis was present in 53% of cases in G1, 50%
in G2 and 13% in G3 (Po0.05). Conclusions: Exposure to chemicals appears
to be an independent risk factor for NASH that presents a peculiar profile. It
is more frequently seen in men younger than non-exposed ones. Steatosis,
fibrosis and cholestasis were frequent histological findings. Co-existing
metabolic factors did not seem to influence clinical or histopathological
presentation. | pt_BR |
| Affilliation | Universidade Federal da Bahia. Faculdade de Medicina. Hospital Universitário Professor Edgard Santos. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Federal da Bahia. Faculdade de Medicina. Hospital Universitário Professor Edgard Santos. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Federal da Bahia. Faculdade de Medicina. Hospital Universitário Professor Edgard Santos. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Federal da Bahia. Faculdade de Medicina. Hospital Universitário Professor Edgard Santos. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Federal da Bahia. Faculdade de Medicina. Hospital Universitário Professor Edgard Santos. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Federal da Bahia. Faculdade de Medicina. Hospital Universitário Professor Edgard Santos. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Federal da Bahia. Faculdade de Medicina. Hospital Universitário Professor Edgard Santos. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Federal da Bahia. Faculdade de Medicina. Hospital Universitário Professor Edgard Santos. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Federal da Bahia. Faculdade de Medicina. Hospital Universitário Professor Edgard Santos. Salvador, BA, Brasil | pt_BR |
| Subject | Industrial hepatotoxicity | pt_BR |
| Subject | Nonalcoholic steatohepatitis | pt_BR |
| Subject | occupational exposure to chemicals | pt_BR |
| e-ISSN | 10.1111/j.1478-3231.2004.0897.x | |
| xmlui.metadata.dc.subject.ods | 09 Indústria, inovação e infraestrutura | |
