| Author | Kubler, Andre | |
| Author | Larsson, Christer | |
| Author | Luna, Brian | |
| Author | Andrade, Bruno de Bezerril | |
| Author | Amaral, Eduardo Pinheiro | |
| Author | Urbanowski, Michael | |
| Author | Orandle, Marlene | |
| Author | Bock, Kevin | |
| Author | Ammerman, Nicole C | |
| Author | Cheung, Laurene S | |
| Author | Winglee, Kathryn | |
| Author | Halushka, Marc | |
| Author | Park, Jin Kyun | |
| Author | Sher, Alan | |
| Author | Friedland, Jon S | |
| Author | Elkington, Paul T | |
| Author | Bishai, William R | |
| Access date | 2017-07-28T17:55:30Z | |
| Available date | 2017-07-28T17:55:30Z | |
| Document date | 2016 | |
| Citation | KUBLER, A. et al. Cathepsin K Contributes to Cavitation and Collagen Turnover in Pulmonary Tuberculosis. Journal of Infectious Diseases, v. 213, p. 618-627, 2014. | pt_BR |
| ISSN | 0022-1899 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/20447 | |
| Description | Andrade, Bruno de Bezerril “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. 1Infectious Diseases and Immunity, Imperial College London, and 2Faculty of Medicine, University of Southampton, United Kingdom; 3Center for Tuberculosis Research and 4Department of Pathology,
Johns Hopkins University School of Medicine, Baltimore, 5Immunobiology Section, Laboratory of Parasitic Diseases, and 6Infectious Diseases Pathogenesis Section, Comparative Medicine Branch,
National Institutes of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland; 7Department of Molecular Biology, Umeå University, Sweden; and 8Division of Rheumatology,
Department of Internal Medicine, Seoul National University Hospital, South Korea | pt_BR |
| Sponsorship | Howard Hughes Medical Institute (to W. R. B.), the National Institutes of Health (NIH; R01 AI 079590, R01 AI037856, and R01 AI036973 to W. R. B. and R33 A1102239 to P. E.), the NIH Intramural Research Program (to A. S., B. B. A., and E. P. A.), Imperial College London (to A. K. and J. S. F.), the Swedish Research Council (to C. L.), and the Swedish Society for Medical Research (to C. L.). | pt_BR |
| Language | eng | pt_BR |
| Publisher | Oxford University Press | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | tuberculose | pt_BR |
| Subject in Portuguese | Cathepsina K | pt_BR |
| Subject in Portuguese | Coelho | pt_BR |
| Subject in Portuguese | Colágeno | pt_BR |
| Subject in Portuguese | Colagenolise | pt_BR |
| Subject in Portuguese | RNAseq | pt_BR |
| Title | Cathepsin K Contributes to Cavitation and Collagen Turnover in Pulmonary Tuberculosis | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1093/infdis/jiv458 | |
| Abstract | Cavitation in tuberculosis enables highly efficient person-to-person aerosol transmission. We performed transcriptomics in the rabbit cavitary tuberculosis model. Among 17 318 transcripts, we identified 22 upregulated proteases. Five type I collagenases were overrepresented: cathepsin K (CTSK), mast cell chymase-1 (CMA1), matrix metalloproteinase 1 (MMP-1), MMP-13, and MMP-14. Studies of collagen turnover markers, specifically, collagen type I C-terminal propeptide (CICP), urinary deoxypyridinoline (DPD), and urinary helical peptide, revealed that cavitation in tuberculosis leads to both type I collagen destruction and synthesis and that proteases other than MMP-1, MMP-13, and MMP-14 are involved, suggesting a key role for CTSK. We confirmed the importance of CTSK upregulation in human lung specimens, using immunohistochemical analysis, which revealed perigranulomatous staining for CTSK, and we showed that CTSK levels were increased in the serum of patients with tuberculosis, compared with those in controls (3.3 vs 0.3 ng/mL; P = .005). | pt_BR |
| Affilliation | Imperial College London. Infectious Diseases and Immunity. Baltimore / Center for Tuberculosis Research. Baltimore | pt_BR |
| Affilliation | Múltipla - ver em Notas | pt_BR |
| Subject | Tuberculosis | pt_BR |
| Subject | Cathepsin K | pt_BR |
| Subject | Rabbit | pt_BR |
| Subject | Collagen | pt_BR |
| Subject | Collagenolysis | pt_BR |
| Subject | RNAseq | pt_BR |
