Author | Cooper, Philip J | |
Author | Chico, Martha E | |
Author | Amorim, Leila Denise Alves Ferreira | |
Author | Sandoval, Carlos | |
Author | Vaca, Maritza | |
Author | Strina, Agostino | |
Author | Campos, Ana Clara Paixão | |
Author | Rodrigues, Laura Cunha | |
Author | Barreto, Maurício Lima | |
Author | Strachan, David P | |
Access date | 2017-08-01T13:40:06Z | |
Available date | 2017-08-01T13:40:06Z | |
Document date | 2016 | |
Citation | COOPER, P. J. et al. Effects of maternal geohelminth infections on allergy in early childhood. Journal of Allergy and Clinical Immunology, v. 137, p. 899-906, 2016. | pt_BR |
ISSN | 0091-6749 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/20478 | |
Description | Barreto, Mauricio Lima “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. | pt_BR |
Sponsorship | Wellcome Trust grant 088862/Z/09/Z. | pt_BR |
Language | eng | pt_BR |
Publisher | American Academy of Allergy, Asthma and Immunology | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Geohelmintos | pt_BR |
Subject in Portuguese | Infecções maternas | pt_BR |
Subject in Portuguese | Atopia | pt_BR |
Subject in Portuguese | Sibilância | pt_BR |
Subject in Portuguese | Eczema | pt_BR |
Subject in Portuguese | Infância | pt_BR |
Title | Effects of maternal geohelminth infections on allergy in early childhood | pt_BR |
Type | Article | pt_BR |
DOI | 10.1016/j.jaci.2015.07.044 | |
Abstract | Maternal geohelminth infections during pregnancy may protect against allergy development in childhood. Objective: We sought to investigate the effect of maternal
geohelminths on the development of eczema, wheeze, and atopy
during the first 3 years of life.
Methods: A cohort of 2404 neonates was followed to 3 years of
age in a rural district in coastal Ecuador. Data on wheeze and
eczema were collected by means of questionnaire and physical
examination at 13, 24, and 36 months of age. Atopy was
measured based on skin prick test (SPT) reactivity to 9 allergens
at 36 months. Maternal stool samples were examined for
geohelminths by microscopy. Data on potential confounders was
collected after birth by questionnaire.
Results: Geohelminths were observed in 45.9% of mothers.
Eczema and wheeze were reported for 17.7% and 25.9%,
respectively, of 2069 (86.1%) children with complete follow-up
to 3 years, and allergen SPT reactivity to any allergen was
present in 17.2% and to house dust mite in 8.7%. Maternal
geohelminth infections were not significantly associated with
eczema (adjusted odds ratio [OR], 1.26; 95% CI, 0.98-1.61),
wheeze (adjusted OR, 1.02; 95% CI, 0.82-1.27), and SPT
reactivity to any allergen (adjusted OR, 0.79; 95% CI, 0.61-
1.01). In subgroup analyses maternal geohelminths were
associated with a significantly reduced risk of SPT reactivity to
mite and other perennial allergens, and maternal ascariasis was
associated with an increased risk of eczema and reduced risk of
SPT reactivity to all allergens.
Conclusion: Our data do not support a protective effect of
maternal infections with geohelminth parasites during
pregnancy against the development of eczema and wheeze in
early childhood, although there was evidence in subgroup
analyses for a reduction in SPT reactivity to house dust
mites and perennial allergens. | pt_BR |
Affilliation | Laboratorio de Investigaciones FEPIS. Quininde / Pontificia Universidad Catolica del Ecuador. Centro de Investigacion en Enfermedades Infecciosas. Quito, Ecuador / Institutes of Infection and Immunity. Quito, Ecuador | pt_BR |
Affilliation | Laboratorio de Investigaciones FEPIS. Quininde | pt_BR |
Affilliation | Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil | pt_BR |
Affilliation | Laboratorio de Investigaciones FEPIS. Quininde | pt_BR |
Affilliation | Laboratorio de Investigaciones FEPIS. Quininde | pt_BR |
Affilliation | Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil | pt_BR |
Affilliation | London School of Hygiene and Tropical Medicine. Faculty of Epidemiology and Population Health. London, WC | pt_BR |
Affilliation | Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil | pt_BR |
Affilliation | St George’s University of London. Public Health Sciences. London, WC | pt_BR |
Subject | Geohelminths | pt_BR |
Subject | Maternal infections | pt_BR |
Subject | Atopy | pt_BR |
Subject | Wheeze | pt_BR |
Subject | Eczema | pt_BR |
Subject | Early childhood | pt_BR |