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| Autor | Cooper, Philip J | |
| Autor | Chico, Martha E | |
| Autor | Amorim, Leila Denise Alves Ferreira | |
| Autor | Sandoval, Carlos | |
| Autor | Vaca, Maritza | |
| Autor | Strina, Agostino | |
| Autor | Campos, Ana Clara Paixão | |
| Autor | Rodrigues, Laura Cunha | |
| Autor | Barreto, Maurício Lima | |
| Autor | Strachan, David P | |
| Fecha de acceso | 2017-08-01T13:40:06Z | |
| Fecha de disponibilización | 2017-08-01T13:40:06Z | |
| Fecha de publicación | 2016 | |
| Referencia | COOPER, P. J. et al. Effects of maternal geohelminth infections on allergy in early childhood. Journal of Allergy and Clinical Immunology, v. 137, p. 899-906, 2016. | pt_BR |
| ISSN | 0091-6749 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/20478 | |
| Descripción | Barreto, Mauricio Lima “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. | pt_BR |
| Promoción | Wellcome Trust grant 088862/Z/09/Z. | pt_BR |
| Idioma | eng | pt_BR |
| Editor | American Academy of Allergy, Asthma and Immunology | pt_BR |
| Derechos de autor | open access | pt_BR |
| Palabras clave en Portugués | Geohelmintos | pt_BR |
| Palabras clave en Portugués | Infecções maternas | pt_BR |
| Palabras clave en Portugués | Atopia | pt_BR |
| Palabras clave en Portugués | Sibilância | pt_BR |
| Palabras clave en Portugués | Eczema | pt_BR |
| Palabras clave en Portugués | Infância | pt_BR |
| Título | Effects of maternal geohelminth infections on allergy in early childhood | pt_BR |
| Tipo del documento | Article | pt_BR |
| DOI | 10.1016/j.jaci.2015.07.044 | |
| Resumen en Inglés | Maternal geohelminth infections during pregnancy may protect against allergy development in childhood. Objective: We sought to investigate the effect of maternal geohelminths on the development of eczema, wheeze, and atopy during the first 3 years of life. Methods: A cohort of 2404 neonates was followed to 3 years of age in a rural district in coastal Ecuador. Data on wheeze and eczema were collected by means of questionnaire and physical examination at 13, 24, and 36 months of age. Atopy was measured based on skin prick test (SPT) reactivity to 9 allergens at 36 months. Maternal stool samples were examined for geohelminths by microscopy. Data on potential confounders was collected after birth by questionnaire. Results: Geohelminths were observed in 45.9% of mothers. Eczema and wheeze were reported for 17.7% and 25.9%, respectively, of 2069 (86.1%) children with complete follow-up to 3 years, and allergen SPT reactivity to any allergen was present in 17.2% and to house dust mite in 8.7%. Maternal geohelminth infections were not significantly associated with eczema (adjusted odds ratio [OR], 1.26; 95% CI, 0.98-1.61), wheeze (adjusted OR, 1.02; 95% CI, 0.82-1.27), and SPT reactivity to any allergen (adjusted OR, 0.79; 95% CI, 0.61- 1.01). In subgroup analyses maternal geohelminths were associated with a significantly reduced risk of SPT reactivity to mite and other perennial allergens, and maternal ascariasis was associated with an increased risk of eczema and reduced risk of SPT reactivity to all allergens. Conclusion: Our data do not support a protective effect of maternal infections with geohelminth parasites during pregnancy against the development of eczema and wheeze in early childhood, although there was evidence in subgroup analyses for a reduction in SPT reactivity to house dust mites and perennial allergens. | pt_BR |
| Afiliación | Laboratorio de Investigaciones FEPIS. Quininde / Pontificia Universidad Catolica del Ecuador. Centro de Investigacion en Enfermedades Infecciosas. Quito, Ecuador / Institutes of Infection and Immunity. Quito, Ecuador | pt_BR |
| Afiliación | Laboratorio de Investigaciones FEPIS. Quininde | pt_BR |
| Afiliación | Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil | pt_BR |
| Afiliación | Laboratorio de Investigaciones FEPIS. Quininde | pt_BR |
| Afiliación | Laboratorio de Investigaciones FEPIS. Quininde | pt_BR |
| Afiliación | Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil | pt_BR |
| Afiliación | Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil | pt_BR |
| Afiliación | London School of Hygiene and Tropical Medicine. Faculty of Epidemiology and Population Health. London, WC | pt_BR |
| Afiliación | Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil | pt_BR |
| Afiliación | Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil | pt_BR |
| Afiliación | St George’s University of London. Public Health Sciences. London, WC | pt_BR |
| Palavras clave en Inglês | Geohelminths | pt_BR |
| Palavras clave en Inglês | Maternal infections | pt_BR |
| Palavras clave en Inglês | Atopy | pt_BR |
| Palavras clave en Inglês | Wheeze | pt_BR |
| Palavras clave en Inglês | Eczema | pt_BR |
| Palavras clave en Inglês | Early childhood | pt_BR |
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