| Author | Cézar, Rodrigo S. | |
| Author | Cerqueira, Bruno Antonio Veloso | |
| Author | Paz, Silvana de Souza da | |
| Author | Barbosa, Cynara Gomes | |
| Author | Moura Neto, José Pereira de | |
| Author | Barreto, José Henrique Silva | |
| Author | Gonçalves, Marilda de Souza | |
| Access date | 2017-08-10T18:45:49Z | |
| Available date | 2017-08-10T18:45:49Z | |
| Document date | 2015 | |
| Citation | CEZAR, Rodrigo S. et al. Outcome of B-Cell Acute Lymphoblastic Leukemia in Brazilian Children: Immunophenotypical, Hematological, and Clinical Evaluation. Journal of Pediatric Hematology/Oncology, v. 37, p. 423–428, Aug. 2015. | pt_BR |
| ISSN | 1077-4114 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/20578 | |
| Language | eng | pt_BR |
| Publisher | Lippincott, Williams & Wilkins | pt_BR |
| Rights | restricted access | pt_BR |
| Subject in Portuguese | Leucemia linfoblástica aguda | pt_BR |
| Subject in Portuguese | Imunofenotipo | pt_BR |
| Subject in Portuguese | Infância | pt_BR |
| Title | Outcome of B-Cell Acute Lymphoblastic Leukemia in Brazilian Children: Immunophenotypical, Hematological, and Clinical Evaluation | pt_BR |
| Type | Article | |
| DOI | 10.1097/MPH.0000000000000358 | |
| Abstract | The aim of this study is to investigate the clinical, hematological, and immunophenotypic characteristics of Brazilian children with B-cell acute lymphoblastic leukemia (B-ALL) to identify prognostic biomarkers of the disease. Thirty-three children newly diagnosed with B-ALL were followed between March 2004 and December 2009. Information about the demographic profile, diagnosis, immunophenotype, clinical manifestations, and disease outcome were gathered from the patients' medical records. Of the 33 patients with B-ALL, 18 were male and 15 female. Eighteen patients were classified as high risk; 13 as low risk, and 2 as true low risk. The frequencies of cluster of differentiation (CD)10, CD19, and CD20 antigens were 69.7%, 81.8%, and 18.2%, respectively. Six patients (18.2%) had aberrant expression of myeloid antigens. At diagnosis, patients immunopositive for CD20 had elevated white blood cell counts (P = 0.018) and lower platelet counts (P = 0.017). The 6-year overall survival was 67.5%± 3.47%. Our results demonstrate the distinct immunophenotypic and prognostic characteristics of patients with B-ALL, which can be related to the Brazilian racial admixture. Consequently, these results will most likely aid in the selection of additional prognostic markers and their use in monitoring the clinical manifestations and treatment response among B-ALL patients. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade do Estado da Bahia. Departamento de Ciências da Vida. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Amazonas. Faculdade de Farmácia. Manaus, AM, Brasil. | pt_BR |
| Affilliation | Hospital São Rafael. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal do Amazonas. Faculdade de Farmácia. Manaus, AM, Brasil / Instituto Nacional de Ciência e Tecnologia do Sangue. Salvador, BA, Brasil. | pt_BR |
| Subject | Acute lymphoblastic leukemia | pt_BR |
| Subject | Immunophenotype | pt_BR |
| Subject | Childhood | pt_BR |
| Embargo date | 2030-12-31 | |
