| Author | Sant`Anna, Flávia Marinho | |
| Author | Velasque, Luciane | |
| Author | Costa, Marli Jane | |
| Author | Schmaltz, Carolina Arana | |
| Author | Morgado, Mariza Gonçalves | |
| Author | Lourenço, Maria Cristina | |
| Author | Grinsztejn, Beatriz | |
| Author | Rolla, Valéria Cavalcanti | |
| Access date | 2017-08-15T13:22:26Z | |
| Available date | 2017-08-15T13:22:26Z | |
| Document date | 2009 | |
| Citation | SANT`ANNA, Flavia Marinho et al. Effectiveness of Highly Active Antiretroviral Therapy (HAART) Used Concomitantly With Rifampicin in Patients with Tuberculosis and AIDS. Brazilian Journal of Infectious Diseases, v. 13, n. 5, p. 362-366, Oct. 2009. | pt_BR |
| ISSN | 1413-8670 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/20611 | |
| Language | eng | pt_BR |
| Publisher | Brazilian Society of Infectious Diseases | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Tuberculose | pt_BR |
| Subject in Portuguese | AIDS | pt_BR |
| Subject in Portuguese | Rifampina | pt_BR |
| Subject in Portuguese | Eficácia | pt_BR |
| Subject in Portuguese | Terapia Antirretroviral de Alta Atividade | pt_BR |
| Title | Effectiveness of Highly Active Antiretroviral Therapy (HAART) Used Concomitantly With Rifampicin in Patients with Tuberculosis and AIDS | pt_BR |
| Type | Article | |
| DOI | 10.1590/S1413-86702009000500010 | |
| Abstract | This study evaluated the effectiveness of two HAART regimens concomitant to rifampicin based tuberculosis (TB) treatment. Patients with TB/HIV diagnosis followed at the TB program between June 2000 and March 2005 were prospectively evaluated. The different HAART regimens in antiretrovirals (ARV) treatment naïve and ARV experienced patients were compared. The effectiveness of HAART was defined as a VL <80 copies/mL from month 4 to month 10 after TB treatment. One hundred and forty-two patients were included. Among these, 68 (47%) were treatment naïve and 76 (53%) previously exposed. Odds ratio (OR) in naïve patients treated with efavirenz (EFV) based regimen (n=42) compared to ritonavir/saquinavir (RTV/SQV) based regimen (n=26) was 8.0 (CI=1.67-38.35, p=0.008). OR from ARV experienced patients treated with RTV/SQV based regimen compared to EFV was 3.08 (CI=0.65-14.6, p=0.15), although with no statistical significance. Better effectiveness and tolerability were observed in antiretrovirals treatment naïve patients using EFV based regimens. Although not statistically significant, a favorable virologic response and a better tolerability were observed in the ARV experienced patients group who received a RTV/SQV based regimen. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Departamento de Imunologia. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Bacteriologia. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Subject | Tuberculosis | pt_BR |
| Subject | AIDS | pt_BR |
| Subject | HAART | pt_BR |
| Subject | Rifampicin | pt_BR |
| Subject | Effectiviness | pt_BR |
| e-ISSN | 1678-4391 | |
