Author | Passaes, Caroline Pereira Bittencourt | |
Author | Guimarães, Monick Lindenmeyer | |
Author | Bello, Gonzalo | |
Author | Morgado, Mariza Gonçalves | |
Access date | 2017-08-15T16:09:45Z | |
Available date | 2017-08-15T16:09:45Z | |
Document date | 2009 | |
Citation | PASSAES, Caroline Pereira; et al. Near Full-Length Genome Characterization of HIV Type 1 Unique BC Recombinant Forms from Southern Brazil. Aids Research and Human Retroviruses. v.25, n.12, 6p, 2009. | pt_BR |
ISSN | 0889-2229 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/20628 | |
Language | eng | pt_BR |
Publisher | Mary Ann Liebert | pt_BR |
Rights | restricted access | pt_BR |
Subject in Portuguese | HIV-1 | pt_BR |
Subject in Portuguese | Estirpes recombinantes de HIV-1 | pt_BR |
Subject in Portuguese | Sul do Brasil | pt_BR |
Subject in Portuguese | Caracterização do Genoma de Longo Comprimento | pt_BR |
Title | Near Full-Length Genome Characterization of HIV Type 1 Unique BC Recombinant Forms from Southern Brazil | pt_BR |
Type | Article | pt_BR |
DOI | 10.1089/aid.2009.0167 | |
Abstract | In southern Brazil, CRF31_BC is the major HIV-1 recombinant form and URFs_BC occurs very infrequently. The
near full-length genomes of four samples displaying a similar recombination profile in the integrase region and
different profiles in the protease=reverse transcriptase regions were analyzed to elucidate their mosaic structure
and to describe for the first time the near full-length genomes of URFs_BC circulating in Brazil. For this purpose,
overlapping PCR amplifications followed by direct sequencing were carried out. Despite the observation that
these samples share a similar recombination profile in the integrase region, phylogenetic, bootscan, and informative
site analyses revealed that the four samples displayed distinct mosaic structures. Additional recombination
events occurred mainly in the gag, reverse transcriptase, and env regions. Our data provide the first
description of the near full-length genomes of URFs_BC in Brazil and offer important insights about the complexity
of HIV-1 recombinant strains currently in circulation in the south of Brazil.. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ. Brasil. | pt_BR |
Subject | HIV-1 | pt_BR |
Subject | Southern Brazil | pt_BR |
Subject | CRF31_BC | pt_BR |
Subject | HIV-1 recombinant strains | pt_BR |
Subject | Near Full-Length Genome Characterization | pt_BR |
e-ISSN | 1931-8405 | |
Embargo date | 2030-01-01 | |