| Author | Pires, Douglas Eduardo Valente | |
| Author | Ascher, David Benjamin | |
| Access date | 2017-08-18T18:33:28Z | |
| Available date | 2017-08-18T18:33:28Z | |
| Document date | 2016 | |
| Citation | PIRES, Douglas Eduardo Valente; ASCHER, David B. mCSM-AB: a web server for predicting antibody-antigen affinity changes upon mutation with graph-based signatures. Nucleic Acids Res., v. 44, n. W1, W469-73, 2016. | pt_BR |
| ISSN | 0305-1048 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/20686 | |
| Language | eng | pt_BR |
| Publisher | Oxford University Press | pt_BR |
| Rights | restricted access | pt_BR |
| Subject in Portuguese | anticorpos | pt_BR |
| Title | mCSM-AB: a web server for predicting antibody-antigen affinity changes upon mutation with graph-based signatures | pt_BR |
| Type | Article | |
| DOI | 10.1093/nar/gkw458 | |
| Abstract | Computational methods have traditionally struggled to predict the effect of mutations in antibody-antigen complexes on binding affinity. This has limited their usefulness during antibody engineering and development, and their ability to predict biologically relevant escape mutations. Here we present mCSM-AB, a user-friendly web server for accurately predicting antibody-antigen affinity changes upon mutation which relies on graph-based signatures. We show that mCSM-AB performs better than comparable methods that have been previously used for antibody engineering. mCSM-AB web server is available at http://structure.bioc.cam.ac.uk/mcsm_ab. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil/University of Cambridge. Department of Biochemistry. Cambridge, UK/University of Melbourne. Department of Biochemistry.Victoria, Australia | pt_BR |
| DeCS | Antibodies/chemistry | pt_BR |
| DeCS | Antigens/immunology | pt_BR |
| DeCS | Protein Engineering | pt_BR |
| Embargo date | 2028-01-01 | |
