| Author | Silva, Andréa Alice da | |
| Author | Pereira, Glaucia Vilar | |
| Author | Souza, Amanda Santos de | |
| Author | Silva, Rafael Rodrigues | |
| Author | Rocha, Mônica Santos | |
| Author | Lannes-Vieira, Joseli | |
| Access date | 2017-08-24T17:43:07Z | |
| Available date | 2017-08-24T17:43:07Z | |
| Document date | 2010 | |
| Citation | SILVA, Andréa Alice da; et al. Trypanosoma cruzi-Induced Central Nervous System Alterations: From the Entry of Inflammatory Cells to Potential Cognitive and Psychiatric Abnormalities. Journal of Neuropathology, v.1, Article ID N100901, 13p, 2010. | pt_BR |
| ISSN | 2090-2344 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/20750 | |
| Language | eng | pt_BR |
| Publisher | Ashdin Publishing Corp. | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Trypanosoma cruzi | pt_BR |
| Subject in Portuguese | Sistema nervoso central | pt_BR |
| Subject in Portuguese | Inflamação | pt_BR |
| Subject in Portuguese | Anormalidades comportamentais | pt_BR |
| Title | Trypanosoma cruzi-Induced Central Nervous System Alterations: From the Entry of Inflammatory Cells to Potential Cognitive and Psychiatric Abnormalities | pt_BR |
| Type | Article | |
| DOI | 10.4303/jnp/N100901 | |
| Abstract | Trypanosoma cruzi, a protozoan parasite and the
causative agent of Chagas disease, is capable of inducing
meningoencephalitis. Independent of the progression from
acute to chronic myocarditis observed in immunocompetent
T. cruzi-infected patients, inflammation of the central nervous
system (CNS) self-resolves during acute infection. In
contrast, in chronically infected immunocompromised Chagas
disease patients, the CNS is a major site of reactivation,
which can lead to severe and frequently fatal meningoencephalitis.
More than one hundred years after the discovery
of Chagas disease, many questions concerning the molecular
mechanisms involved in the induction and resolution of
T. cruzi-provoked meningoencephalitis remain unanswered.
The study of murine models that reproduce crucial aspects
of T. cruzi-elicited CNS inflammation has not only shed light
on some of these questions, but it has also raised additional
ones. Here, we discuss our results in the context of the current
literature, questioning the involvement of CNS alterations
caused by the inflammation and parasite in the behavioral
abnormalities observed during T. cruzi infection. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia das Interações. Rio de Janeiro, RJ. Brasil / Universidade Federal Fluminense. Escola de Medicina. Departamento de Patologia. Niterói, RJ, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia das Interações. Rio de Janeiro, RJ. Brasil / Universidade Federal Fluminense. Escola de Medicina. Departamento de Patologia. Niterói, RJ, Brasil | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Ciências Biomédicas. Laboratório de Farmacologia da Neuroplasticidade e do Comportamento. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia das Interações. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Ciências Biomédicas. Laboratório de Farmacologia da Neuroplasticidade e do Comportamento. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia das Interações. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Subject | Trypanosoma cruzi | pt_BR |
| Subject | central nervous system | pt_BR |
| Subject | inflammation | pt_BR |
| Subject | behavioral abnormalities | pt_BR |
| Embargo date | 2030-01-01 | |
