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AutorPereira, Denyson Santana
AutorMorais, Janaína Pereira
AutorSantana, Danielle Gomes
AutorSantos, Cliomar Alves
AutorThomazzi, Sara Maria
AutorSantos, Charles Estevam dos
AutorAntoniolli, Angelo Roberto
AutorBezerra, Daniel Pereira
AutorCamargo, Enilton Aparecido
Fecha de acceso2017-08-28T13:47:44Z
Fecha de disponibilización2017-08-28T13:47:44Z
Fecha de publicación2013
ReferenciaPEREIRA, D. S. et al. Effects of the ethanol extract of the inner bark of Syderoxylum obtusifolium in the cyclophosphamide-induced cystitis in rats. Journal of Medicinal Plants Research, v. 7, n. 20, p. 1411-1417, 2013.pt_BR
ISSN1996-0875pt_BR
URIhttps://www.arca.fiocruz.br/handle/icict/20777
DescripciónBezerra, Daniel Pereira “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.pt_BR
PromociónFundação de Apoio a Pesquisa e Inovação Tecnológica (FAPITEC/SE; No 019.203.02344/2009-7) and Conselho Nacional de Pesquisa e Desenvolvimento Científico (CNPq; No 562478/2010-8)pt_BR
Idiomaengpt_BR
EditorAcademic Journalspt_BR
Derechos de autoropen accesspt_BR
Palabras clave en PortuguésCiclofosfamidapt_BR
Palabras clave en Portuguésinflamaçãopt_BR
Palabras clave en PortuguésPeroxidação de lipídeospt_BR
Palabras clave en PortuguésCistitept_BR
TítuloEffects of the ethanol extract of the inner bark of Syderoxylum obtusifolium in the cyclophosphamide-induced cystitis in ratspt_BR
Tipo del documentoArticlept_BR
Resumen en InglésIn this study, the ethanol extract of the inner bark of the Syderoxylum obtusifolium (EESob) was tested in the model of cyclophosphamide-induced hemorrhagic cystitis. Male Wistar rats were submitted to the injection of cyclophosphamide, 1 h after the treatment with EESob (200 or 400 mg/kg) or vehicle. After 24 h, the urinary bladder was excised and the edema, myeloperoxidase activity and malondialdehyde formation were measured. Also, myeloperoxidase activity and malondialdehyde formation in lung, spleen and liver and leukocyte counts in the peripheral blood were evaluated. Injection of cyclophosphamide increased myeloperoxidase activity and edema. The former was inhibited by the EESob at 400 mg/kg, but the latter was not affected. Although cyclophosphamide did not alter the bladder malondialdehyde formation, pre-treatment with EESob at both doses markedly increased this parameter. Lung and liver parameters or leukocyte counts were not altered by EESob. The spleen myeloperoxidase activity and malondialdehyde formation were not affected by cyclophosphamide, but were increased by the treatment with EESob. These results suggests that EESob administration to rats decrease myeloperoxidase activity in bladder tissue, but is accompanied by lipoperoxidation in this tissue, as well as in spleen, which do not support the use of EESob to treat cystitis.pt_BR
AfiliaciónFederal University of Sergipe. Department of Physiology. São Cristóvão, SE, Brazilpt_BR
AfiliaciónFederal University of Sergipe. Department of Physiology. São Cristóvão, SE, Brazilpt_BR
AfiliaciónFederal University of Sergipe. Department of Physiology. São Cristóvão, SE, Brazilpt_BR
AfiliaciónFederal University of Sergipe. Department of Physiology. São Cristóvão, SE, Brazilpt_BR
AfiliaciónFederal University of Sergipe. Department of Physiology. São Cristóvão, SE, Brazilpt_BR
AfiliaciónFederal University of Sergipe. Department of Physiology. São Cristóvão, SE, Brazilpt_BR
AfiliaciónFederal University of Sergipe. Department of Physiology. São Cristóvão, SE, Brazilpt_BR
AfiliaciónFederal University of Sergipe. Department of Physiology. São Cristóvão, SE, Brazilpt_BR
AfiliaciónFederal University of Sergipe. Department of Physiology. São Cristóvão, SE, Brazilpt_BR
Palavras clave en InglêsSyderoxylum obtusifoliumpt_BR
Palavras clave en InglêsCyclophosphamidept_BR
Palavras clave en InglêsInflammationpt_BR
Palavras clave en InglêsLipid peroxidationpt_BR
Palavras clave en InglêsHemorrhagic cystitispt_BR


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