| Author | Medeiros, Gabriela A. | |
| Author | Silvério, Jaline C. | |
| Author | Marino, Ana Paula M. P. | |
| Author | Roffê, Ester | |
| Author | Vieira, Valeska | |
| Author | Palhares, Karina Kroll | |
| Author | Carvalho, Cristiano E. | |
| Author | Silva, Andréa Alice | |
| Author | Teixeira, Mauro M. | |
| Author | Lannes-Vieira, Joseli | |
| Access date | 2017-08-29T13:49:00Z | |
| Available date | 2017-08-29T13:49:00Z | |
| Document date | 2009 | |
| Citation | MEDEIROS, Gabriela A. et al. Treatment of chronically Trypanosoma cruzi-infected mice with a CCR1/CCR5 antagonist (Met-RANTES) results in amelioration of cardiac tissue damage. Microbes and Infection, v.11, p.264-273, 2009. | pt_BR |
| ISSN | 1286-4579 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/20804 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | restricted access | pt_BR |
| Subject in Portuguese | Trypanosoma cruzi | pt_BR |
| Subject in Portuguese | Doença de Chagas | pt_BR |
| Subject in Portuguese | Miocardite | pt_BR |
| Subject in Portuguese | Doenças do coração | pt_BR |
| Title | Treatment of chronically Trypanosoma cruzi-infected mice with a CCR1/CCR5 antagonist (Met-RANTES) results in amelioration of cardiac tissue damage | pt_BR |
| Type | Article | pt_BR |
| Abstract | The comprehension of the molecular mechanisms leading to Trypanosoma cruzi-elicited heart dysfunction might contribute to design novel
therapeutic strategies aiming to ameliorate chronic Chagas disease cardiomyopathy. In C3H/He mice infected with the low virulence T. cruzi
Colombian strain, the persistent cardiac inflammation composed mainly of CCR5þ T lymphocytes parallels the expression of CC-chemokines in
a pro-inflammatory IFN-g and TNF-a milieu. The chronic myocarditis is accompanied by increased frequency of peripheral CCR5þLFA-1þ T
lymphocytes. The treatment of chronically T. cruzi-infected mice with Met-RANTES, a selective CCR1/CCR5 antagonist, led to a 20e30%
decrease in CD4þ cell numbers as well as IL-10, IL-13 and TNF-a expression. Further, Met-RANTES administration impaired the recompartmentalization
of the activated CD4þCCR5þ lymphocytes. Importantly, Met-RANTES treatment resulted in significant reduction in
parasite load and fibronectin deposition in the heart tissue. Moreover, Met-RANTES treatment significantly protected T. cruzi-infected mice
against connexin 43 loss in heart tissue and CK-MB level enhancement, markers of heart dysfunction. Thus, our results corroborate that
therapeutic strategies based on the modulation of CCR1/CCR5-mediated cell migration and/or effector function may contribute to cardiac tissue
damage limitation during chronic Chagas disease. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia das Interações. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia das Interações. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia das Interações. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Departamento de Patologia. Niterói, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia das Interações. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia das Interações. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia das Interações. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia das Interações. Rio de Janeiro, RJ. Brasil / Universidade Federal de Minas Gerais. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Departamento de Patologia. Niterói, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia das Interações. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Subject | Trypanosoma cruzi | pt_BR |
| Subject | Chagas Disease | pt_BR |
| Subject | myocarditis | pt_BR |
| Subject | heart disease | pt_BR |
| Subject | Met-RANTES | pt_BR |
| e-ISSN | 1769-714X | |
| Embargo date | 2030-01-01 | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
