| Author | Lannes-Vieira, Joseli | |
| Author | Silverio, Jaline Coutinho | |
| Author | Pereira, Isabela Resende | |
| Author | Vinagre, Nathália Ferreira | |
| Author | Carvalho, Cristiano Marcelo Espinola | |
| Author | Paiva, Cláudia Neto | |
| Author | Silva, Andréa Alice da | |
| Access date | 2017-08-29T15:11:50Z | |
| Available date | 2017-08-29T15:11:50Z | |
| Document date | 2009 | |
| Citation | LANNES-VIEIRA, Joseli; et al. Chronic Trypanosoma cruzi-elicited cardiomyopathy: from the discovery to the proposal of rational therapeutic interventions targeting cell adhesion molecules and chemokine receptors - how to make a dream come true. Mem Inst Oswaldo Cruz, v.104, Suppl. I, p. 226-235, 2009. | pt_BR |
| ISSN | 0074-0276 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/20812 | |
| Language | eng | pt_BR |
| Publisher | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Doença de Chagas | pt_BR |
| Subject in Portuguese | Trypanosoma cruzi | pt_BR |
| Subject in Portuguese | Cardiomiopatia | pt_BR |
| Subject in Portuguese | Quimiocina | pt_BR |
| Subject in Portuguese | Receptores de quimiocina | pt_BR |
| Subject in Portuguese | Moléculas de adesão celular | pt_BR |
| Title | Chronic Trypanosoma cruzi-elicited cardiomyopathy: from the discovery to the proposal of rational therapeutic interventions targeting cell adhesion molecules and chemokine receptors - how to make a dream come true | pt_BR |
| Type | Article | |
| Abstract | One hundred years ago, Carlos Chagas discovered a new disease, the American trypanosomiasis. Chagas and co-workers later characterised the disease’s common manifestation, chronic cardiomyopathy, and suggested that parasitic persistence coupled with inflammation was the key underlying pathogenic mechanism. Better comprehension of the molecular mechanisms leading to clinical heart afflictions is a prerequisite to developing new therapies that ameliorate inflammation and improve heart function without hampering parasite control. Here, we review recent data showing that distinct cell adhesion molecules, chemokines and chemokine receptors participate in anti-parasite immunity and/or detrimental leukocyte trafficking to the heart. Moreover, we offer evidence that CC-chemokine receptors may be attractive therapeutic targets aiming to regain homeostatic balance in parasite/host interaction thereby improving prognosis, supporting that it is becoming a non-phantasious proposal. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia das Interações. Rio de Janeiro, RJ. Brasil / Fundação Oswaldo Cruz. Programa Integrado de Doença de Chagas-Fiocruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Programa Integrado de Doença de Chagas-Fiocruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Programa Integrado de Doença de Chagas-Fiocruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Programa Integrado de Doença de Chagas-Fiocruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Programa Integrado de Doença de Chagas-Fiocruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro - UFRJ. Instituto de Microbiologia Professor Paulo de Góes. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Departamento de Patologia. Niterói, RJ, Brasil. | pt_BR |
| Subject | Chagas Disease | pt_BR |
| Subject | Trypanosoma cruzi | pt_BR |
| Subject | cardiomyopathy | pt_BR |
| Subject | chemokine | pt_BR |
| Subject | chemokine receptors | pt_BR |
| Subject | cell adhesion molecules | pt_BR |
| e-ISSN | 1678-8060 | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
