| Author | Van-Dunem, Joaquim C. V. D. | |
| Author | Rodrigues, Laura C. | |
| Author | Alencar, Luiz Claudio Arraes | |
| Author | Militão-Albuquerque, Maria de Fátima Pessoa | |
| Author | Ximenes, Ricardo Arraes de Alencar | |
| Access date | 2017-09-22T19:47:02Z | |
| Available date | 2017-09-22T19:47:02Z | |
| Document date | 2015 | |
| Citation | VAN-DUNEM, J. C. V. D. et al. Effectiveness of the First Dose of BCG against Tuberculosis among HIV-Infected, Predominantly Immunodeficient Children. BioMed Research International, v. 2015, p. 275029, 2015. | pt_BR |
| ISSN | 2314-6141 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/21095 | |
| Language | por | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Vacina BCG | pt_BR |
| Subject in Portuguese | Coinfecção | pt_BR |
| Subject in Portuguese | Tuberculose | pt_BR |
| Subject in Portuguese | Infecções por HIV | pt_BR |
| Title | Effectiveness of the First Dose of BCG against Tuberculosis among HIV-Infected, Predominantly Immunodeficient Children | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1155/2015/275029 | |
| Abstract | The objective of this study was to estimate the protective effect of Bacille Calmette-Guérin (BCG) vaccine against tuberculosis among (predominantly immunodeficient) HIV-infected children in Angola. A hospital-based case-control study was conducted with 230 cases, children coinfected with tuberculosis, and 672 controls, HIV-infected children from the same hospital, aged 18 months to 13 years. The presence of a vaccination scar was taken as a proxy marker for BCG vaccination. The crude effectiveness was 8% (95% CI: -26 to 32) and the adjusted effectiveness was 30% (95% CI: -75 to 72). The present study suggests that BCG does not have a protective effect against tuberculosis among immunodeficient HIV-infected children. Since BCG is no longer given to HIV-infected children, the study may not be replicated. Accepting that these findings should be considered with caution, they are nonetheless likely to be the last estimate of BCG efficacy in a sufficiently powered study. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil | pt_BR |
| Subject | Adolescent | pt_BR |
| Subject | BCG Vaccine | pt_BR |
| Subject | Case-Control Studies | pt_BR |
| Subject | Child | pt_BR |
| Subject | Child, Preschool | pt_BR |
| Subject | Coinfection | pt_BR |
| Subject | Female | pt_BR |
| Subject | HIV Infections | pt_BR |
| Subject | Humans | pt_BR |
| Subject | Infant | pt_BR |
| Subject | Male | pt_BR |
| Subject | Mycobacterium bovis | pt_BR |
| Subject | Tuberculosis | pt_BR |
| Subject | Vaccination | pt_BR |
| DeCS | Vacina BCG | pt_BR |
| DeCS | administração & dosagem | pt_BR |
| DeCS | Coinfecção | pt_BR |
| DeCS | imunologia | pt_BR |
| DeCS | microbiologia | pt_BR |
| DeCS | prevenção & controle | pt_BR |
| DeCS | Infecções por HIV | pt_BR |
| DeCS | Tuberculose | pt_BR |
| DeCS | Humanos | pt_BR |
| DeCS | Adolescente | pt_BR |
| DeCS | Estudos de Casos e Controles | pt_BR |
| DeCS | Criança | pt_BR |
| DeCS | Pré-escolar | pt_BR |
| DeCS | Feminino | pt_BR |
| DeCS | Masculino | pt_BR |
| DeCS | Lactente | pt_BR |
| DeCS | Mycobacterium bovis | pt_BR |
| DeCS | Tuberculose | pt_BR |
| DeCS | Vacinação | pt_BR |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
| xmlui.metadata.dc.subject.ods | 05 Igualdade de gênero | |
