Author | Malta, Monica Siqueira | |
Author | Magnanini, Monica Maria Ferreira | |
Author | Steffanie A. Strathdee | |
Author | Bastos, Francisco Inácio Pinkusfeld Monteiro | |
Access date | 2011-05-02T18:28:44Z | |
Available date | 2011-05-02T18:28:44Z | |
Document date | 2010 | |
Citation | MALTA, Monica Siqueira et. al. Adherence to antiretroviral therapy among HIV-infected drug users: a meta-analysisAIDS and Behavior, v.14, p.731–747, 2010. | en_US |
ISSN | 1573-3254 | |
URI | https://www.arca.fiocruz.br/handle/icict/2281 | |
Language | eng | en_US |
Publisher | Elsevier | en_US |
Rights | open access | en_US |
Title | Adherence to antiretroviral therapy among HIV-infected drug users: a meta-analysis | en_US |
Type | Article | en_US |
DOI | 10.1007/s10461-008-9489-7 | |
Abstract | Abstract We conducted a meta-analysis of studies
assessing adherence to highly active antiretroviral therapy
(HAART) and a qualitative systematic review of factors
associated with better HAART outcomes among HIV?
drug users (DU). Thirty-eight studies were considered,
which analyzed 14,960 patients (11,394 HIV? DU,
76.2%). Overall adherence (pooled percent of DU classified
as adherent in each study) was 0.60 (95% CI: 0.52–
0.68), similar to levels identified by studies conducted with
HIV? patients who are not drug users. Time frame used to
measure adherence was an independent predictor of interstudy
heterogeneity. The systematic review identified better
HAART outcomes among former DU, those with less
severe psychiatric conditions, those receiving opioid substitution
therapy and/or psychosocial support. Patients
initiating HAART with lower viral load and higher CD4
counts, and those without co-infections also had better
treatment outcomes. Our findings suggest that HIV? DU
tend to be inappropriately assumed to be less adherent and
unlikely to achieve desirable treatment outcomes, when
compared to their non-DU cohort. | en_US |
Affilliation | Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Departamento Ciência Social. Rio de Janeiro, RJ, Brasil | en_US |
Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Estudos de Saúde Coletiva. Rio de Janeiro, RJ, Brasil | en_US |
Affilliation | University of California. School of Medicine, San Diego. Division of International Health and Cross Cultural Medicine. Department of Family and Preventive Medicine. San Diego, CA, USA. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto de Comunicação e Informação Científica e Tecnológica em Saúde. Laboratório de Informação em Saúde. Rio de Janeiro, RJ, Brasil | en_US |
Subject | HIV | en_US |
Subject | Aids | en_US |
Subject | Meta-analysis | en_US |
Subject | Adherence | en_US |
Subject | Drug use | en_US |