| Author | Felix, Gabriela Espirito Santo | |
| Author | Zheng, Yonglan | |
| Author | Olopade, Olufunmilayo I | |
| Access date | 2017-10-17T17:41:56Z | |
| Available date | 2017-10-17T17:41:56Z | |
| Document date | 2017 | |
| Citation | FELIX, G. E. S.; ZHENG, Y.; OLOPADE, O. I. Mutations in context: implications of BRCA testing in diverse populations. Familial Cancer, 2017. | pt_BR |
| ISSN | 1389-9600 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/22851 | |
| Sponsorship | Coordination for the Improvement of Higher Education Personnel (CAPES), Susan G. Komen for the Cure, and John and Editha Kapoor Charitable Foundation. | pt_BR |
| Language | eng | pt_BR |
| Publisher | Springer Verlag | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Testes genéticos | pt_BR |
| Subject in Portuguese | Câncer de mama | pt_BR |
| Subject in Portuguese | Disparidade | pt_BR |
| Subject in Portuguese | Medicina de precisão | pt_BR |
| Title | Mutations in context: implications of BRCA testing in diverse populations | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1007/s10689-017-0038-2 | |
| Abstract | Cancer is a common non-communicable disease worldwide, although it exhibits differential population trends in incidence and mortality rates. The differences relate to population structure, environmental risk factors as well as health system organization. This article discusses the potential impact of genetic testing on population health, focusing in particular on the mutational spectrum of breast cancer susceptibility genes in diverse populations. We identify the need for improved access to, and increased investment in, comprehensive cancer risk assessment and genetic testing as well as cancer control measures that take into account lifestyle, environmental, and social factors in understudied minority groups. | pt_BR |
| Affilliation | University of Chicago. Center for Clinical Cancer Genetics & Global Health. Chicago, USA / Laboratório de Imunologia e Biologia Molecular, Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | University of Chicago. Center for Clinical Cancer Genetics & Global Health. Chicago, USA | pt_BR |
| Affilliation | University of Chicago. Center for Clinical Cancer Genetics & Global Health. Chicago, USA / University of Chicago. Department of Medicine. Chicago, USA | pt_BR |
| Subject | Genetic testing | pt_BR |
| Subject | Breast cancer | pt_BR |
| Subject | Disparity | pt_BR |
| Subject | Precision medicine | pt_BR |
| xmlui.metadata.dc.subject.ods | 01 Erradicação da pobreza | |
| xmlui.metadata.dc.subject.ods | 10 Redução das desigualdades | |
