| Author | Barroso, David Eduardo | |
| Author | Carvalho, D. M. | |
| Author | Casagrande, S. T. | |
| Author | Rebelo, M. C. | |
| Author | Soares, V. | |
| Author | Zahner, V. | |
| Author | Solari, C. A. | |
| Author | Nogueira, S. A. | |
| Access date | 2017-10-19T11:31:24Z | |
| Available date | 2017-10-19T11:31:24Z | |
| Document date | 2010 | |
| Citation | BARROSO, David Eduardo; et al. Microbiological epidemiological history of meningococcal disease in Rio de Janeiro, Brazil. Braz J Infect Dis., v.14, n.3, p.242-251, 2010. | pt_BR |
| ISSN | 1413-8670 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/22878 | |
| Language | eng | pt_BR |
| Publisher | Brazilian Society of Infectious Diseases | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Neisseria meningitidis | pt_BR |
| Subject in Portuguese | Meningite | pt_BR |
| Subject in Portuguese | Sepse | pt_BR |
| Subject in Portuguese | doença meningocócica | pt_BR |
| Subject in Portuguese | Epidemia | pt_BR |
| Title | Microbiological epidemiological history of meningococcal disease in Rio de Janeiro, Brazil | pt_BR |
| Type | Article | |
| Abstract | The main objectives of the present study were to investigate the clinical and laboratory features of
meningococcal disease in the city of Rio de Janeiro, Brazil, during the overlap of 2 epidemics in the
1990s. We conducted a study of a series of cases of meningococcal disease admitted in a Meningitis
Reference Hospital. All clinical isolates available were analyzed by means of microbiological epidemiological
markers. In 1990, Neisseria meningitidis serogroup B:4,7:P1.19,15, 1.7,1 sulfadiazine-resistant
of the ET-5 complex emerged causing epidemic disease. Despite mass vaccination campaign
(VaMengoc B+C®), the ET-5 clone remained hyperendemic after the epidemic peaked. In 1993 to
1995, an epidemic of serogroup C belonged to the cluster A4 overlapped, with a signifi cant shift in
the age distribution toward older age groups and an increase of sepsis. Serogroup C epidemics are
a recurrent problem in Rio de Janeiro, which can be hindered with the introduction of a conjugate
vaccine. We hope the data presented here brings useful information to discuss vaccines strategies and
early management of suspected cases. | pt_BR |
| Affilliation | Instituto Estadual de Infectologia São Sebastião. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Departamento de Medicina Preventiva. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bioquímica e Biologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Departamento de Medicina Preventiva. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Instituto Adolfo Lutz. Seção de Bacteriologia. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Instituto Estadual de Infectologia São Sebastião. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Instituto Estadual de Infectologia São Sebastião. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bioquímica e Biologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bacteriologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Instituto Estadual de Infectologia São Sebastião. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Departamento de Medicina Preventiva. Rio de Janeiro, RJ, Brasil . | pt_BR |
| Subject | Neisseria meningitidis | pt_BR |
| Subject | meningococcal disease | pt_BR |
| Subject | epidemic | pt_BR |
| Subject | meningitis | pt_BR |
| Subject | sepsis | pt_BR |
| Subject | Rio de Janeiro | pt_BR |
| e-ISSN | 1678-4391 | |
| Embargo date | 2030-01-01 | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
