| Author | Ferreira, Júnia Raquel Dutra | |
| Author | Aleluia, Milena Magalhães | |
| Author | Figueiredo, Camylla Vilas Boas | |
| Author | Vieira, Larissa Castro de Lima | |
| Author | Santiago, Rayra Pereira | |
| Author | Guarda, Caroline Conceição da | |
| Author | Barbosa, Cynara Gomes | |
| Author | Oliveira, Ricardo Riccio | |
| Author | Adorno, Elisângela Vitória | |
| Author | Gonçalves, Marilda de Souza | |
| Access date | 2017-10-25T12:19:38Z | |
| Available date | 2017-10-25T12:19:38Z | |
| Document date | 2017 | |
| Citation | FERREIRA, J. R. D. et al. Evaluation of Cardiometabolic Parameters among Obese Women Using Oral Contraceptives. Frontiers in Endocrinology, v. 8, sept. 2017. | pt_BR |
| ISSN | 1664-2392 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/22954 | |
| Sponsorship | “Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ)” | pt_BR |
| Language | eng | pt_BR |
| Publisher | Frontiers Media | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Contraceptivos orais combinados | pt_BR |
| Subject in Portuguese | Obesidade | pt_BR |
| Subject in Portuguese | Parâmetros cardiometabólicos | pt_BR |
| Subject in Portuguese | Mulheres | pt_BR |
| Subject in Portuguese | Proteína C-reativa | pt_BR |
| Subject in Portuguese | Colesterol de lipoproteínas de alta densidade | pt_BR |
| Subject in Portuguese | Risco cardiovascular | pt_BR |
| Title | Evaluation of Cardiometabolic Parameters among Obese Women Using Oral Contraceptives | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.3389/fendo.2017.00256 | |
| Abstract | Combined oral contraceptive (COC) use has been associated with an unfavorable impact on carbohydrate and lipid metabolism in diverse populations of normal weight and obese women. The present study aimed to evaluate the cardiometabolic and inflammatory profiles of women in northeastern Brazil with respect to COC use and obesity. Methods: We performed a cross-sectional study to verify cardiovascular parameters, including blood pressure (BP), fasting serum glucose, lipid, and inflammatory profile, in a population of women aged 15–45 years, considering obesity and COC use. Our sample consisted of 591 women, 481 women who were COC users, and 110 age-matched women who were COC non-users, classified as obese and non-obese according to BMI.Results: COC use and obesity were associated with increased systolic (p ≤ 0.001)
and diastolic BP (p = 0.001), blood glucose (p ≤ 0.001), total cholesterol (p = 0.008),
low-density lipoprotein cholesterol (p ≤ 0.001), very low-density lipoprotein cholesterol
(p ≤ 0.001), triglycerides (p ≤ 0.001), ferritin (p = 0.006), C-reactive protein (CRP)
(p ≤ 0.001), and nitric oxide metabolites (p ≤ 0.001), as well as decreased high-density
lipoprotein cholesterol (HDL-c) (p ≤ 0.001) in comparison to controls. CRP and HDL-c
levels in obese COC users were determined to be outside reference range values. The
odds of having lower levels of HDL-c and elevated CRP increased among obese COC
users. COC use was independently associated with low levels of HDL-c, especially
second-generation progestins (p < 0.001; OR = 8.976; 95% CI 2.786–28.914).
Conclusion: Obesity and COC use were associated with alterations in lipid and inflammatory
cardiometabolic parameters, particularly increased CRP levels and decreased
HDL-c, which are considered markers of cardiovascular disease (CVD) risk. Given the
need to prevent unintended pregnancy among obese women, together with weight
loss counseling, it is important to evaluate the most effective and safest contraceptive
methods to avoid the potential risk of developing CVD. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Federal da Bahia. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Federal da Bahia. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Federal da Bahia. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Salvador, BA, Brasil | pt_BR |
| Subject | Combined oral contraceptives | pt_BR |
| Subject | Obesity | pt_BR |
| Subject | Cardiometabolic parameters | pt_BR |
| Subject | Women | pt_BR |
| Subject | C-reactive protein | pt_BR |
| Subject | High-density lipoprotein cholesterol | pt_BR |
| Subject | Cardiovascular risk | pt_BR |
| xmlui.metadata.dc.subject.ods | 05 Igualdade de gênero | |
