| Author | Bozza, Patrícia T. | |
| Author | Abreu, Ilka Bakker | |
| Author | Xavier, Roberta A. Navarro | |
| Author | Melo, Christianne Bandeira | |
| Access date | 2017-11-01T16:02:43Z | |
| Available date | 2017-11-01T16:02:43Z | |
| Document date | 2011 | |
| Citation | BOZZA, Patricia T. et al. Lipid body function in eicosanoid synthesis: Anupdate. Prostaglandins, Leukotrienes and Essential Fatty Acids, v.85, n.5, p.205-213, 2011. | pt_BR |
| ISSN | 0952-3278 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/23029 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Função do corpo lipídico | pt_BR |
| Subject in Portuguese | Eicosanóide | pt_BR |
| Subject in Portuguese | Inflamação | pt_BR |
| Subject in Portuguese | Infecção | pt_BR |
| Subject in Portuguese | processo neoplásico | pt_BR |
| Title | Lipid body function in eicosanoid synthesis: an update | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.plefa.2011.04.020 | |
| Abstract | Eicosanoids (prostaglandins, leukotrienes and lipoxins) are signaling lipids derived from arachidonic acid metabolism that have important roles in physiological and pathological processes. Lately, intracellular compartmentalization of eicosanoid-synthetic machinery has emerged as a key component in the regulation of eicosanoid synthesis and functions. Over the past years substantial progresses have been made demonstrating that precursors and enzymes involved in eicosanoid synthesis localize at lipid bodies (also known as lipid droplets) and lipid bodies are distinct sites for eicosanoid generation. Here we will review the current knowledge on the functions of lipid bodies as specialized intracellular sites of compartmentalization of signaling with major roles in eicosanoid formation within cells engaged in inflammatory, infectious and neoplastic process. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro, Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro, Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Lipid body function | pt_BR |
| Subject | eicosanoid synthesis | pt_BR |
| Subject | inflammatory process | pt_BR |
| Subject | infectious process | pt_BR |
| Subject | neoplastic process | pt_BR |
| e-ISSN | 1532-2823 | |
| Embargo date | 2030-01-01 | |
