| Author | Rezende, Antonio M. | |
| Author | Assis, Ludmila A. | |
| Author | Nunes, Eduardo C. | |
| Author | Lima, Tamara D. da Costa | |
| Author | Marchini, Fabricio K. | |
| Author | Freire, Eden R. | |
| Author | Reis, Christian R. S. | |
| Author | Melo Neto, Osvaldo P. de | |
| Access date | 2017-11-16T11:39:41Z | |
| Available date | 2017-11-16T11:39:41Z | |
| Document date | 2014 | |
| Citation | REZENDE, A. M. et al. The translation initiation complex eIF3 in trypanosomatids and other pathogenic excavates--identification of conserved and divergent features based on orthologue analysis. BMC genomics, v. 15, p. 1175, 23 dez. 2014. | pt_BR |
| ISSN | 1471-2164 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/23198 | |
| Language | eng | pt_BR |
| Rights | open access | pt_BR |
| MeSH | Eukaryotic Initiation Factor-3 | pt_BR |
| MeSH | chemistry | pt_BR |
| MeSH | Eukaryotic Initiation Factor-3 | pt_BR |
| MeSH | genetics | pt_BR |
| MeSH | Trichomonadida | pt_BR |
| MeSH | genetics | pt_BR |
| MeSH | Animals | pt_BR |
| MeSH | Computational Biology | pt_BR |
| MeSH | Amino Acid Sequence | pt_BR |
| MeSH | Conserved Sequence | pt_BR |
| MeSH | Genetic Variation | pt_BR |
| MeSH | Humans | pt_BR |
| Subject in Portuguese | Fator de iniciação da tradução | pt_BR |
| Subject in Portuguese | síntese de proteínas | pt_BR |
| Subject in Portuguese | eIF3 | pt_BR |
| Subject in Portuguese | protozoários | pt_BR |
| Title | The translation initiation complex eIF3 in trypanosomatids and other pathogenic excavates--identification of conserved and divergent features based on orthologue analysis | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1186/1471-2164-15-1175 | |
| Abstract | The initiation of translation in eukaryotes is supported by the action of several eukaryotic Initiation Factors (eIFs). The largest of these is eIF3, comprising of up to thirteen polypeptides (eIF3a through eIF3m), involved in multiple stages of the initiation process. eIF3 has been better characterized from model organisms, but is poorly known from more diverged groups, including unicellular lineages represented by known human pathogens. These include the trypanosomatids (Trypanosoma and Leishmania) and other protists belonging to the taxonomic supergroup Excavata (Trichomonas and Giardia sp.). | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil. | pt_BR |
| Subject | Translation initiation factor | pt_BR |
| Subject | Protein synthesis | pt_BR |
| Subject | eIF3 | pt_BR |
| Subject | Protozoa | pt_BR |
